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Polycystic ovary syndrome and fibrocystic breast disease: is there any association?

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Abstract

Objective

We aimed to investigate the association between a polycystic ovary syndrome (PCOS) and fibrocystic breast disease.

Methods

A total of 93 women, aged between 17 and 36 years, not using oral contraceptives, were entered ın this case-control study. Laboratory, clinical and ultrasound findings were used to diagnose PCOS. The study group was consisted of 53 PCOS women and the control group consisted of 40 women. Breast ultrasonography was performed for all patients. Fibrocystic breast disease is described as common benign changes involving the tissues of the breast.

Results

Twenty-one (39.6%) of 53 women with a PCOS had fibrocystic breast disease. Five (8%) of 40 controls had fibrocystic breast disease. The difference between the groups was statistically significant (p = 0.004). Relative risk (95% CIs) was 3.17 (1.31–7.68). Overall sonographic benign breast pathologies were significantly higher in the PCOS group (p = 0.036).

Conclusion

This study showed a statistically significant association between a PCOS and fibrocystic breast disease. Women with a PCOS should be evaluated for fibrocystic breast disease.

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References

  1. Polson DW, Adamas J, Wadsworth J, Franks S (1988) Polycystic ovaries-a common finding in normal women. Lancet 1:870–872. doi:10.1016/S0140-6736(88)91612-1

    Article  PubMed  CAS  Google Scholar 

  2. Solomon CG (1999) The epidemiology of polycystic ovary syndrome. Prevalence and associated disease risks. Endocrinol Metab Clin North Am 28:247–263. doi:10.1016/S0889-8529(05)70069-4

    Article  PubMed  CAS  Google Scholar 

  3. Lobo RA, Carmina E (2000) The importance of diagnosing the polycystic ovary syndrome. Ann Intern Med 132:989–993

    PubMed  CAS  Google Scholar 

  4. Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF (2000) A prospective study of the prevalenceof the polycystic ovary syndrome in unselected Caucasianwomen from Spain. J Clin Endocrinol Metab 85:2434–2438. doi:10.1210/jc.85.7.2434

    Article  PubMed  CAS  Google Scholar 

  5. Gadducci A, Gargini A, Palla E, Fanucchi A, Genazzani AR (2005) Polycystic ovary syndrome and gynecological cancer: is there a link? Gynecol Endocrinol 20:200–208. doi:10.1080/09513590400021201

    Article  PubMed  Google Scholar 

  6. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2003) Revised consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41–47. doi:10.1093/humrep/deh098

    Article  Google Scholar 

  7. Gorins A, Denis C (1995) Effects of progesterone and progestational hormones on the mammary gland. Arch Anat Cytol Pathol 43:28–35

    PubMed  CAS  Google Scholar 

  8. Thalaband JC, Sitruk-Ware R, Kuttenn F, Mauvais-Jarvis P (1986) Endocrine markers in benign breast diseases. Zentralbl Gynakol 108:354–358

    Google Scholar 

  9. D’Amelio R, Farris M, Grande S, Feraudo E, Iuliano A, Zichella L (2001) Association between polycystic ovary and fibrocystic breast disease. Gynecol Obstet Invest 51:134–137. doi:10.1159/000052909

    Article  PubMed  Google Scholar 

  10. Soran A, Talbott EO, Zborowski JV, Wilson JW (2005) The prevalence of benign breast disease in women with polycystic ovary syndrome: a reviewe of a 12-year follow-up. Int J Clin Pract 59:795–797. doi:10.1111/j.1742-1241.2005.00417.x

    Article  PubMed  CAS  Google Scholar 

  11. Dunaif A (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18:774–800. doi:10.1210/er.18.6.774

    Article  PubMed  CAS  Google Scholar 

  12. Lobo RA (1995) A disorder without identiy: ‘HCA’, ‘PCO’, ‘PCOD’, ‘PCOS’, ‘SLS’. What are we to call it? Fertil Steril 63:1158–1160

    PubMed  CAS  Google Scholar 

  13. Devit J (1981) Clinical benign disorders of the breast and carcinoma of the breast. Surg Gynecol Obstet 152:437–440

    Google Scholar 

  14. Feig SA (1989) The role of ultrasound in a breast imaging center. Semin Ultrasound CT MR 10:90–105

    PubMed  CAS  Google Scholar 

  15. Hilton SVW, Leopold GR, Olson LK et al (1986) Real-time breast sonography: application in 300 consecutive patients. AJR 147:479–486

    PubMed  CAS  Google Scholar 

  16. Anderson KE, Sellers TA, Chen PL, Rich SS, Hong CP, Folsom AR (1997) Association of Stein–Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. Cancer 79:494–499. doi:10.1002/(SICI)1097-0142(19970201)79:3<494::AID-CNCR10>3.0.CO;2-Z

    Article  PubMed  CAS  Google Scholar 

  17. Mauvais-Jarvis P Sitruk-Ware R, Kutten F, Sterkers N (1979) Luteal phase insufficiency: a common pathophysiological factor in development of benign and malignant breast disease. In: Bulbrook RD, Taylor DJ (eds) Commentaries on research in breast disease, Alan R. Liss, New York, pp 25–29

  18. Dogliotti L, Orlandi F, Angeli A (1989) The endocrine basis of benign breast disorders. World J Surg 13:674–679. doi:10.1007/BF01658413

    Article  PubMed  CAS  Google Scholar 

  19. Sitruk-Ware LR, Sterkers N, Mowszowics I, Mauvais-Jarvis P (1977) Inaequate corpus luteal function in women with benign breast disease. J Clin Endocrinol Metab 44:771

    Article  PubMed  CAS  Google Scholar 

  20. Torris R, Parodi S, Fontana V, Pensa F, Casella C, Barreca A, De Palo G, Costa A, Decensi A (1998) Effects of fenretinine on plasma IGF-1 and IGFBP-3 in early breast cancer patients. Int J Cancer 76:787–790. doi:10.1002/(SICI)1097-0215(19980610)76:6<787::AID-IJC3>3.0.CO;2-U

    Google Scholar 

  21. Gebauer G, Jager W, Lang N (1998) mRNA expression of components of the insulin-like growth factor system in breast cell lines, tissues and metastatic breast cancer cells. Anticancer Res 18:1991–1995

    Google Scholar 

  22. Ng EH, Ji CY, Tan PH, Lin V, Soo KC, Lee KO (1998) Altered serum levels of insulin-like growth-factor binding protein in breast cancer patients. Ann Surg Oncol 5:194–201. doi:10.1007/BF02303854

    Article  PubMed  CAS  Google Scholar 

  23. Spritzer PM, Morsch DM, Witgen D (2005) Polycystic ovary syndrome associated neoplasms. Arq Bras Endocrinol Metabol 49:805–810. doi:10.1590/S0004-27302005000500022

    PubMed  Google Scholar 

  24. Gadducci A, Gargini A, Palla E, Fanucchi A, Genazzani AR (2005) Polycystic ovary syndrome and gynecological cancer: is there a link? Gynecol Endocrinol 20:200–208. doi:10.1080/09513590400021201

    Article  PubMed  Google Scholar 

  25. Lefebvre J (1997) The protein of fibrocystic breast disease-methods of measurement and clinical implications. Bull Acad Natl Med 181:1487–1500

    PubMed  CAS  Google Scholar 

  26. Thalaband JC, Sitruk-Ware R, Kuttenn F, Mauvais-Jarvis P (1986) Endocrine markers in benign breast diseases. Zentralbl Gynakol 108:354–358

    Google Scholar 

  27. Panaritis V, Despotidis P, Kyriakidis A (2004) Diameter of mammary terminal ducts as an additional tool in evaluation of women with polycystic ovarium disease. Arch Gynecol Obstet 270:252–254. doi:10.1007/s00404-003-0555-0

    Article  PubMed  CAS  Google Scholar 

  28. Soran A, Talbott EO, Zborowski JV, Wilson JW (2005) The prevalence of benign breast disease in women with polycystic ovary syndrome: a reviewe of a 12-year follow-up. Int J Clin Pract 59:795–797. doi:10.1111/j.1742-1241.2005.00417.x

    Article  PubMed  CAS  Google Scholar 

  29. D’Amelio R, Farris M, Grande S, Feraudo E, Iuliano A (2000) Incidence of fibrocystic disease of the breast in women with polycystic ovary. Clinico-instrumental study. Minerva Ginecol 52:321–325

    PubMed  Google Scholar 

  30. Wild S, Pierpoint T, Jacobs H, McKeigue P (2000) Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study. Hum Fertil 3:101–105. doi:10.1080/1464727002000198781

    Article  Google Scholar 

  31. Balen A (2001) Polycystic ovary syndrome and cancer. Hum Reprod Update 7:522–525. doi:10.1093/humupd/7.6.522

    Article  PubMed  CAS  Google Scholar 

  32. Atiomo WU, El-Mahdi E, Hardiman P (2003) Familial associations in women with polycystic ovary syndrome. Fertil Steril 80:143–145. doi:10.1016/S0015-0282(03)00502-8

    Article  PubMed  Google Scholar 

  33. Gammon MD, Thompson WD (1991) Polycystic ovaries and the risk of breast cancer. Am J Epidemiol 134:818–824

    PubMed  CAS  Google Scholar 

  34. Anderson KE, Sellers TA, Chen PL, Rich SS, Hong CP, Folsom AR (1997) Association of Stein–Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. Cancer 79:494–499. doi:10.1002/(SICI)1097-0142(19970201)79:3<494::AID-CNCR10>3.0.CO;2-Z

    Article  PubMed  CAS  Google Scholar 

  35. Atiomo WU, El-Mahdi E, Hardiman P (2003) Familial associations in women with polycystic ovary syndrome. Fertil Steril 80:143–145. doi:10.1016/S0015-0282(03)00502-8

    Article  PubMed  Google Scholar 

  36. Wild S, Pierpoint T, Jacobs H, McKeigue P (2000) Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study. Hum Fertil 3:101–105. doi:10.1080/1464727002000198781

    Article  Google Scholar 

  37. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA et al (2005) Benign breast disease and the risk of breast cancer. N Engl J Med 353:229–237. doi:10.1056/NEJMoa044383

    Article  PubMed  CAS  Google Scholar 

  38. Wong YC, Xie B (2001) The role of androgens in mammary carcinogenesis. Ital J Anat Embryol 106:111–125

    PubMed  CAS  Google Scholar 

  39. Xie B, Tsao SW, Wong YC (1999) Sex hormone-induced mammary carcinogenesis in female noble rats: the role of androgens. Carcinogenesis 20:1597–1606. doi:10.1093/carcin/20.8.1597

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Fatih University School of Medicine, Cayhane Sk. No: 43/10 Gazi Osman Pasa, Ankara, Turkey

    Ilknur Inegol Gumus, Dilek Dogan & Nilgun Ozturk Turhan

  2. Department of Radiology, Fatih University School of Medicine, Ankara, Turkey

    Asli Koktener

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  1. Ilknur Inegol Gumus
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Correspondence to Ilknur Inegol Gumus.

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Gumus, I.I., Koktener, A., Dogan, D. et al. Polycystic ovary syndrome and fibrocystic breast disease: is there any association?. Arch Gynecol Obstet 280, 249–253 (2009). https://doi.org/10.1007/s00404-008-0889-8

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  • DOI: https://doi.org/10.1007/s00404-008-0889-8

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