Inhibin A levels and severity of preeclampsia
- 108 Downloads
To evaluate the use of third trimester inhibin A levels to assess the severity of preeclampsia.
Materials and methods
Blood samples were taken from women diagnosed with mild and severe preeclampsia during the third trimester of pregnancy. Blood samples were collected in plain tubes, centrifuged and stored at −80°C until analyzed. All serum samples were measured for inhibin A levels by enzyme-linked immunosorbent assays.
Inhibin A levels were greater in the severe (1,435.9 ± 603.2 pg/mL) than in the mild preeclampsia group (1,021.9 ± 438.8 pg/mL, P = 0.014).
Inhibin A levels rise with increasing severity of disease. However, there is considerable overlap of serum inhibin A levels in women with mild and severe preeclampsia. Inhibin A is therefore not a useful adjunct for the classification of preeclampsia.
KeywordsInhibin A Preeclampsia Pregnancy Severity
- 4.Gratacos E, Casals E, Gomez O, Aibar C, Cararach V, Alonso PL, Fortuny A (2000) Inhibin A serum levels in proteinuric and nonproteinuric pregnancy-induced hypertension: evidence for placental involvement in gestational hypertension? Hypertens Pregnancy 19:315–321. doi:10.1081/PRG-100101993 PubMedCrossRefGoogle Scholar
- 11.Phupong V, Dejthevaporn T, Tanawattanacharoen S, Manotaya S, Tannirandorn Y, Charoenvidhya D (2003) Predicting the risk of preeclampsia and small for gestational age infants by uterine artery Doppler in low-risk women. Arch Gynecol Obstet 268:158–161. doi:10.1007/s00404-002-0361-0 PubMedCrossRefGoogle Scholar
- 16.Silver HM, Lambert-Messerlian GM, Star JA, Hogan J, Canick JA (1999) Comparison of maternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies. Am J Obstet Gynecol 180:1131–1137. doi:10.1016/S0002-9378(99)70606-X PubMedCrossRefGoogle Scholar