Abstract
We report a case of a neonate who was diagnosed as having congenital leukemia after presenting with an intracranial hemorrhage. The chief symptom was early-onset jaundice due to the hemorrhage. The intracranial hemorrhage and post-hemorrhage hydrocephalus advanced. In addition, the leukemia worsened leading to death at 14 days old. The possibility of leukemia, although rare, should be considered as a cause of intracranial hemorrhage in term babies.
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Bajwa RP, Skinner R, Windebank KP, Reid MM (2004) Demographic study of leukaemia presenting within the first 3 months of life in the Northern Health Region of England. J Clin Pathol 57:186–188. doi:10.1136/jcp.2003.12039
Pierce MI (1959) Leukemia in the newborn infant. J Pediatr 54:691–706. doi:10.1016/S0022-3476(59)80132-3
Oski FA, Naimann JL (1982) Hematologic problems in the newborn. WB Saunders Co., Philadelphia, pp 237–240
Perkins SL, Segal GH, Kjeldsberg CR (1995) Classification of non-Hodgkin’s lymphomas in children. Semin Diagn Pathol 12:303–313
Makino M, Mikawa M, Ishikawa N (1998) A case with congenital leukemia diagnosed at Birth. J Jpn Soc Neon Med 34:846–851 (in Japanese language)
Heibel M, Heber R, Bechinger D, Kornhuber HH (1993) Early diagnosis of perinatal cerebral lesions in apparently full-term newborns by ultrasound of brain. Neuroradiology 35:85–91. doi:10.1007/BF00593960
Wong JPL, Seow WT, Yeo GSH (2004) Characteristics of six newborn infants with postnatal findings of severe intracranial hemorrhage. Ann Acad Med Singapore 33:789–792
Jhawar BS, Ranger A, Steven D, Del Maestro RF (2003) Risk factors for intracranial hemorrhage among full-term infants: a case-control study. Neurosurgery 52:581–590. doi:10.1227/01.NEU.0000047819.33177.72
Jhawar BS, Ranger A, Steven D, Del Maestro RF (2005) A follow-up study of infants with intracranial hemorrhage at full-term. Can J Neurol Sci 32:332–339
Wald BR, Heisel MA, Ortega JAF (1982) Frequency of early death in children with acute leukemia presenting with hyperleukocytosis. Cancer 50:150–153 doi:10.1002/1097-0142(19820701)50:1<150::AID-CNCR2820500128>3.0.CO;2-A
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Ito, M., Nishimaki, S., Nakano, Y. et al. A case of fetal leukemia with intracranial hemorrhage and early-onset jaundice. Arch Gynecol Obstet 279, 599–601 (2009). https://doi.org/10.1007/s00404-008-0784-3
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DOI: https://doi.org/10.1007/s00404-008-0784-3