Abstract
Introduction
Primary leiomyosarcoma of the broad ligament (LBL) is a very rare and highly malignant gynecological tumor.
Materials and methods
A 45 year old hysterectomized woman with this rare tumor is presented. Treatment consisted of resection of the tumor along with omental and peritoneal sampling and adjuvant chemotherapy. No evidence of metastasis was present after 15 months of follow up.
Conclusion
Complete surgery along with adjuvant chemotherapy or radiation and a close follow up for recurrence are advocated to optimize disease free survival.
Similar content being viewed by others
References
Gardner GH, Greene RR, Peckham R (1957) Tumors of the broad ligament. Am J Obstet Gynecol 73:536–555
Lowell DM, Karsh J (1968) Leiomyosarcoma of the broad ligament. A case report. Obstet Gynecol 32:107–110
Ullman AS, Roumell TL (1973) A case report. Leiomyosarcoma of the broad ligament. Mich Med 72:411–414
Weed JC Jr, Podger K (1976) Leiomyosarcoma of the broad ligament coincident with ductal carcinoma of the breast. South Med J 69(10):1379–1380
DiDomenico A, Stangl F, Bennington J (1982) Leiomyosarcoma of the broad ligament. Gynecol Oncol 13(3):412–415. doi:10.1016/0090-8258(82)90080-4
Raj Kumar G (1982) Leiomyosarcoma of probable ovarian or broad ligament origin. Br J Obstet Gynaecol 89(4):327–329
Herbold D, Fu Y, Silbert S (1983) Leiomyosarcoma of the broad ligament. A case report and literature review with follow up. Am J Surg Pathol 7(3):285–292. doi:10.1097/00000478-198304000-00007
Shimm DS, McDonough JF (1987) Leiomyosarcoma of the broad ligament: report of a case. Gynecol Oncol 26(1):123–126. doi:10.1016/0090-8258(87)90079-5
Lee JF, Yang YC, Lee YN et al (1991) Leiomyosarcoma of the broad ligament—report of two cases. Chin Med J 48:59–65
Cheng WF, Lin HH, Chen CK et al (1995) Leiomyosarcoma of the broad ligament: a case report and literature review. Gynecol Oncol 56(1):85–89. doi:10.1006/gyno.1995.1014
Pekin T, Eren F, Pekin O (2000) Leiomyosarcoma of the broad ligament: case report and literature review. Eur J Gynaecol Oncol 21(3):318–319
Shah A, Finn C, Light A (2003) Leiomyosarcoma of the broad ligament: a case report and literature review. Gynecol Oncol 90(2):450–452. doi:10.1016/S0090-8258(03)00208-7
Agarwal U, Dahiya P, Sangwan K (2003) Leiomyosarcoma of the broad ligament mimicking as ovarian carcinoma—a case report. Arch Gynecol Obstet 269(1):55–56. doi:10.1007/s00404-002-0418-0
El Idrissi F, Fadli A (2004) Leiomyosarcoma of the broad ligament. Presse Med 33(15):1004–1005. doi:10.1016/S0755-4982(04)98823-9
Murialdo R, Usset A, Guido T et al (2005) Leiomyosarcoma of the broad ligament: a case report and review of literature. Int J Gynecol Cancer 15(6):1226–1229. doi:10.1111/j.1525-1438.2005.00176.x
Ben AF, Jouini H, Nasr M et al (2007) Primary leiomyosarcoma of broad ligament. Tunis Med 85(7):591–595
Zaloudek C, Michael RH (2004) Mesenchymal tumours of the uterus. In: Kurman RJ (ed) Blaustein’s Pathology of the female genital tract, 5th edn. Springer, New York, pp 561–615
Coindre JM, Nguyen BB, Bonichon F et al (1988) Histopathologic grading in spindle cell soft tissue sarcomas. Cancer 61(11):2305–2309. doi:10.1002/1097-0142(19880601)61:11<2305::AID-CNCR2820611126>3.0.CO;2-M
Eltabbakh GH (2007) Broad ligament lipoma presenting as a pelvic mass: a case report. J Reprod Med 52(6):543–544
Cobellis L, Pecori E, Rigatti F et al (2007) A rare case of female pelvic mass: angioleiomyoma of the broad ligament. Eur Gynecol Oncol 28(5):418–420
Zubor P, Kajo K, Szunyogh N et al (2007) A solitary fibrous tumor in the broad ligament of the uterus. Pathol Res Pract 203(7):555–560. doi:10.1016/j.prp.2007.02.005
Kir G, Eren S, Akoz I et al (2003) Leiomyosarcoma of the broad ligament arising in a pre-existing pure neurilemmoma-like leiomyoma. Eur J Gynaecol Oncol 24(6):505–506
Jahier H, Gares R, Ganeval C (1958) Recurrent leiomyosarcoma of the left broad ligament. Bull Fed Soc Gynecol Obstet Lang Fr 10(2):167–168
Zeloudex C, Brenda WN (2006) The ovary and fallopian tube. In: Silverberg SG, Delellis RA, Frable WJ et al (eds) Silverberg’s principles and practice of surgical pathology and cytopathology, 4th edn. Churchill Livingstone, Philadelphia, pp 1987–2062
Gadducci A, Cosio S, Romanini A et al (2008) The management of patients with uterine sarcoma: a debated clinical challenge. Crit Rev Oncol Hematol 65(2):129–142. doi:10.1016/j.critrevonc.2007.06.011
Scurry JP, Sumithran E (1989) An assessment of the value of frozen sections in gynecological surgery. Pathology 21(3):159–163. doi:10.3109/00313028909061051
Hensley ML, Blessing JA, Mannel R, Rose PG (2008) Fixed-dose rate gemcitabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II trial. Gynecol Oncol 109(3):329–334. doi:10.1016/j.ygyno.2008.03.010
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Duhan, N., Singh, S., Kadian, Y.S. et al. Primary leiomyosarcoma of broad ligament: case report and review of literature. Arch Gynecol Obstet 279, 705–708 (2009). https://doi.org/10.1007/s00404-008-0777-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-008-0777-2