Abstract
Background
To present a case of primary malignant melanoma of the cervix.
Case
The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix. Histopathology showed a malignant neoplasm with increased vascularity, indicating the possibility of a primary uterine cervical melanoma. Diagnosis of malignant melanoma was confirmed with immunohistochemistry, which showed diffuse positive reactions for S-100 protein and HBM-45, with no reaction for epithelial markers, namely cytokeratin AE1/AE3 and epithelial membrane antigen. An extensive search for a melanotic lesion in skin and in uveal tract was performed to verify the distinct site of melanoma. The tumor was stage IB1 according to the International Federation of Gynecology and Obstetrics classification.The patient underwent radical Wertheim–Meigs hysterectomy, bilateral salpingo-oopherectomy, and retroperitoneal pelvic lympadenectomy. Radiotherapy or chemotherapy was not performed in the postoperative period. She is now free of the disease 10 months after the operation.
Conclusion
Primary malignant melanoma of the cervix is a rare cervical malignancy.
Similar content being viewed by others
References
Morrow CP, DiSaia PJ (1976) Malignant melanoma of female genitalia: a clinical analysis. Obstet Gynecol Surv 31(4):233–271
Podczaski E, Abt A, Kaminski P et al (1990) A patient with multiple malignant melanoma of lower genital tract. Gynecol Oncol 37(3):422–426. doi:10.1016/0090-8258(90)90380-4
Gupta R, Singh S, Mandal AK (2005) Primary malignant melanoma of the cervix—a case report. Indian J Cancer 42(4):201–204
Ma SQ, Bai CM, Zhong S, Yu XH, Lang JH (2005) Clinical analysis of primary malignant melanoma of the cervix. Chin Med Sci J 20(4):257–260
Mousavi AS, Fakor F, Nazari Z, Ghaemmaghami F, Hashemi FA, Jamali M (2006) Primary malignant melanoma of the uterine cervix: case report and review of the literature. J Low Genit Tract Dis 10(4):258–263. doi:10.1097/01.lgt.0000229564.11741.4e
Jin B, Goldsmith A, Budev H, Al-Abbadi M (2007) Primary melanoma of the uterine cervix after supracervical hysterectomy. A case report. Acta Cytol 51(1):86–88
Dematos P, Tyler D, Seigler HF (1988) Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medikal Center. Surgery 124(1):38–48
Gupta S, Sodhani P, Jain S (2003) Primary malignant melanoma of uterine cervix: a rare entity diagnosed on fine needle aspiration cytology—report of a case. Cytopathology 14(3):153–156. doi:10.1046/j.1365-2303.2003.00014.x
Mordel N, Mor-Yosef S, Ben Baruch N, Anteby SO (1989) Malignant melanoma of uterine cervix: case report and review of the literature. Gynecol Oncol 32(3):375–380. doi:10.1016/0090-8258(89)90645-8
Morris HJ, Taylor HB (1966) Melanomas of the vagina. Am J Clin Pathol 46(4):420–426
Jones HW, Droegmueller W, Makowski EL (1971) A primary melanocarcinoma of the cervix. Am J Obstet Gynecol 111(1):959–963
Cantuaria G, Angioli R, Nahmias J, Estape R, Penalver M (1999) Primary malignant melanoma of the uterine cervix. Gynecol Oncol 75(1):170–174. doi:10.1006/gyno.1999.5491
Clark KC, Butz WR, Hapke MR (1999) Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol 18(3):265–273. doi:10.1097/00004347-199907000-00013
Santoso JT, Kucera PR, Ray J (1990) Primary malignant melanoma of the uterine cervix. Two case reports and a century’s review. Obstet Gynecol Surv 45(11):733–740. doi:10.1097/00006254-199011000-00003
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yücesoy, G., Kus, E., Cakiroglu, Y. et al. Primary malignant melanoma of the cervix: report of a case. Arch Gynecol Obstet 279, 573–575 (2009). https://doi.org/10.1007/s00404-008-0761-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-008-0761-x