Skip to main content

Advertisement

SpringerLink
Log in

Evaluation of the sexual function and quality of life in raloxifene treated postmenopausal women

  • Original Article
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To evaluate the net effect of raloxifene on overall quality of life and sexual function in postmenopausal women.

Methods

The study was performed in the Gynecology and Obstetrics outpatient clinic of Gazi University Faculty of Medicine between January 2002 and February 2005. Fifty postmenopausal women, in whom raloxifene was indicated for prevention and treatment of osteoporosis, were considered the study group. Fifty postmenopausal women who were not osteoporotic were enrolled as the control group. Participants completed a questionnaire composed of several parts (GRISS, BDI and ISI), at the beginning and end of the 12-month treatment period.

Results

Two groups were similar to each other with respect to total GRISS scores at the beginning and at the end of the study (P = 0.929 and P = 0.508; respectively). Raloxifene was associated with a significant improvement from baseline in the total scores of BDI (P = 0.0001), whereas this improvement was not significantly different from the control group (P = 0.216). With regard to ISI scores, there were no differences between groups in total scores. Raloxifene use did not seem to affect subscores of ISI either.

Conclusions

This study failed to prove any deleterious effect of raloxifene on quality of life and sexual functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kaufert PA, Gilbert P, Tate R (1992) The Manitoba project: a reexamination of the link between menopause and depression. Maturitas 14:143–155. doi:10.1016/0378-5122(92)90006-P

    Article  PubMed  CAS  Google Scholar 

  2. Gelfand MM (2000) Sexuality among older women. J Womens Health Gend Based Med 9:15–20. doi:10.1089/152460900318812

    Article  Google Scholar 

  3. Daly E, Gray A, Barlow D, McPherson K, Roche M, Vessey M (1993) Measuring the impact of menopausal symptoms on quality of life. BMJ 307:836–840

    Article  PubMed  CAS  Google Scholar 

  4. Hays J, Ockene JK, Brunner RL, Kotchen JM, Manson JE, Patterson RE et al (2003) Effects of estrogen plus progestin on health-related quality of life. N Engl J Med 348:1839–1854. doi:10.1056/NEJMoa030311

    Article  PubMed  CAS  Google Scholar 

  5. Wells G, Tugwell P, Shea B, Guyatt G, Peterson J, Zytaruk N et al (2002) Meta-analyses of therapies for postmenopausal osteoporosis. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women. Endocr Rev 23:529–539. doi:10.1210/er.2001-5002

    Article  PubMed  CAS  Google Scholar 

  6. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick MD et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principle results from the Women’s Health Initiative randomized controlled trial. Writing Group for the Women’s Health Initiative Investigators. JAMA 288:321–333. doi:10.1001/jama.288.3.321

    Article  PubMed  CAS  Google Scholar 

  7. Lewis JS, Jordan VC (2005) Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance. Mutat Res 591:247–263. doi:10.1016/j.mrfmmm.2005.02.028

    PubMed  CAS  Google Scholar 

  8. Katznellenbongen BS, Katznellenbongen JA (2002) Defining the ‘S’ in SERM’s. Science 295:2380–2381. doi:10.1126/science.1070442

    Article  Google Scholar 

  9. Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL et al (2002) Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 346:967–974. doi:10.1056/NEJMoa012952

    Article  PubMed  CAS  Google Scholar 

  10. Bryant HU, Wilson PK, Adrian MD, Cole HW, Philips DL, Dodge JA et al (1996) Selective estrogen receptor modulators: pharmacological profile in the rat uterus. J Soc Gynecol Investig 3:152A. doi:10.1016/1071-5576(96)82635-9

    Article  Google Scholar 

  11. Rust J, Golombok S (1986) The GRISS: a psychometric instrument for the assessment of sexual dysfunction. Arch Sex Behav 15(2):157–165. doi:10.1007/BF01542223

    Article  PubMed  CAS  Google Scholar 

  12. Tuğrul C, Öztan N, Kabakçı E (1993) Golombok-Rust Cinsel Doyum Ölçeği’nin Standardizasyon Çalışması. Turk Psikiyatri Derg 4:83–88

    Google Scholar 

  13. Hisli N (1988) A validation study of Beck Depression Inventory. Psikoloji Derg 6:118–122

    Google Scholar 

  14. Aslan S, Cöngöloğlu E, Gülçat Z ve ark (2003) Uykusuzluk şiddeti indeksi geçerlik çalışması. 4. Ulusal biyolojik psikiyatri kongresi, 7–11 Mayıs 2003, Ankara s: 127–129

  15. Fink G, Sumner BE, Rosie R, Grace O, Quinn JP (1996) Estrogen control of central neurotransmission: effect on mood, mental state, and memory. Cell Mol Neurobiol 16:325–344. doi:10.1007/BF02088099

    Article  PubMed  CAS  Google Scholar 

  16. Zhou W, Koldzic-Zivanovic N, Clarke CH, de Beun R, Wassermann K, Burry PS et al (2002) Selective estrogen receptor modulator effects in the rat brain. Neuroendocrinology 75:24–33. doi:10.1159/000048218

    Article  PubMed  CAS  Google Scholar 

  17. Nickelsen T, Lufkin EG, Riggs BL, Cox DA, Crook THIII (1999) Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in postmenopausal women. Psychoneuroendocrinology 24:115–128. doi:10.1016/S0306-4530(98)00041-9

    Article  PubMed  CAS  Google Scholar 

  18. Walsh BW, Kuller LH, Wild RA, Paul S, Farmer M, Lawrence JB et al (1998) Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA 279:1445–1451. doi:10.1001/jama.279.18.1445

    Article  PubMed  CAS  Google Scholar 

  19. Cummings SR, Eckert S, Krueger KA et al (1999) The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA 281:2189–2197. doi:10.1001/jama.281.23.2189

    Article  PubMed  CAS  Google Scholar 

  20. Strickler R, Stovall DW, Merritt D, Shen W, Wong M, Silfen SL (2000) Raloxifene and estrogen effects on quality of life in healthy postmenopausal women: a placebo-controlled randomized trial. Obstet Gynecol 96:359–365. doi:10.1016/S0029-7844(00)00937-6

    Article  PubMed  CAS  Google Scholar 

  21. Haskell SG, Richardson ED (2004) The effect of raloxifene on cognitive function in postmenopausal women: a randomized clinical trial. Conn Med 68(6):355–358

    PubMed  Google Scholar 

  22. Scharla S, Oertel H, Helsberg K, Kessler F, Langer F, Nickelsen T (2006) Skeletal pain in postmenopausal women with osteoporosis: prevalence and course during raloxifene treatment in a prospective observational study of 6 months duration. Curr Med Res Opin 22(12):2393–2402. doi:10.1185/030079906X154097

    Article  PubMed  CAS  Google Scholar 

  23. Bachmann GA (1993) Sexual function in the peri-menopause. Obstet Gynecol Clin North Am 20:379–389

    PubMed  CAS  Google Scholar 

  24. Dennerstein L, Dudley EC, Hopper JL, Burger H (1997) Sexuality, hormones and the menopausal transition. Maturitas 26:83–93. doi:10.1016/S0378-5122(96)01093-6

    Article  PubMed  CAS  Google Scholar 

  25. Vardy MD, Lindsay R, Scotti RJ, Mikhail M, Richart RM, Nieves J et al (2003) Short-term urogenital effects of raloxifene, tamoxifen, and estrogen. Am J Obstet Gynecol 189:81–88. doi:10.1067/mob.2003.374

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey

    A. Biri, Umit Korucuoglu, B. Ciftci, N. Bozkurt & H. Guner

  2. Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey

    M. N. Ilhan

Authors
  1. A. Biri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Umit Korucuoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. N. Ilhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Ciftci
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Bozkurt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Guner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Umit Korucuoglu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Biri, A., Korucuoglu, U., Ilhan, M.N. et al. Evaluation of the sexual function and quality of life in raloxifene treated postmenopausal women. Arch Gynecol Obstet 279, 505–509 (2009). https://doi.org/10.1007/s00404-008-0752-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0752-y

Keywords

Search

Navigation