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Chondromatous differentiation in clear cell carcinoma of the ovary: a rare finding challenging the differential diagnosis

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Abstract

Objective

Ovarian surface epithelial tumors rarely have heterologous elements including bone or cartilage that may appear histologically benign or malignant. There are a few case reports in the literature of ovarian tumors containing chondromatous areas.

Case

We report a clear cell carcinoma of the bilateral ovary showing chondromatous differentiation in a 56-year-old woman. Histopathologic study of the specimen showed clear cell carcinoma with many small foci of chondromatous differentiation. Immunohistochemical studies demonstrated positivity for S-100 confirming the diagnosis. The patient was alive with disease on chemotherapy for 16 months.

Conclusion

A rare case of benign appearing chondromatous differentiation in an ovarian clear cell carcinoma of the ovary is described, and the significance of this finding is discussed.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, Pamukkale University, Denizli, Turkey

    Metin Akbulut

  2. Department of Pathology, School of Medicine, Ege University, Bornova, Izmir, Turkey

    Osman Zekioglu

  3. Department of Obstetrics and Gynecology, School of Medicine, Ege University, Bornova, Izmir, Turkey

    Mustafa Cosan Terek

  4. Department of Pathology, School of Medicine, Ege University, Bornova, Izmir, Turkey

    Necmettin Ozdemir

Authors
  1. Metin Akbulut
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  2. Osman Zekioglu
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  3. Mustafa Cosan Terek
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  4. Necmettin Ozdemir
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Corresponding author

Correspondence to Osman Zekioglu.

Additional information

This paper was accepted as a poster at the 17th National Congress of Pathology, October 8–13, 2007, Istanbul.

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Akbulut, M., Zekioglu, O., Terek, M.C. et al. Chondromatous differentiation in clear cell carcinoma of the ovary: a rare finding challenging the differential diagnosis. Arch Gynecol Obstet 278, 569–572 (2008). https://doi.org/10.1007/s00404-008-0624-5

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  • DOI: https://doi.org/10.1007/s00404-008-0624-5

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