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Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor

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Abstract

Objective

Adenofibroma is a form of mixed mesodermal tumor in which epithelial and stromal components are benign, and usually arises in the endometrium of postmenopausal women. We report a case of lipoadenofibroma of the endometrium that appeared as an intracavitary mass, which is very unusual because endometrioid adenofibroma rarely contains mature adipose tissue, only the second such case described in detail.

Case

An endometrial polypoid mass measuring 1,5 cm with maximum diameter was found incidentally during total abdominal hysterectomy for keratinizing large cell carcinoma of the cervix in a 60-year-old woman. The endometrial polypoid mass was found to be a lipoadenofibroma composed predominantly of collagenated fibrous stroma populated by cystically dilated and occasionally crowded glands lined with proliferative endometrium, intermingled with abundant mature adipose tissue.

Conclusion

We suggest that uterine adenofibromas with lipomatous areas belong to the family of mixed tumor of Mullerian origin. We discuss the pathogenesis of this entity and review the previously documented similar cases.

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References

  1. Zaloudek CJ, McUsa M, Norris HJ (1981) Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer 48:354–366

    Article  PubMed  CAS  Google Scholar 

  2. Horie Y, Ikawa S, Kadowaki K, Minagawa Y, Kigawa J, Terakawa N (1995) Lipoadenofibroma of the uterine corpus: report of a new variant of adenofibroma (benign müllerian mixed tumor). Arch Pathol Lab Med 119:274–276

    PubMed  CAS  Google Scholar 

  3. Ober WB (1959) Uterine sarcomas: histogenesis and taxonomy. Ann NY Acad Sci 75:568–585

    Article  PubMed  CAS  Google Scholar 

  4. Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D (2006) Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature. Eur J Gynaecol Oncol 27(1):73–77

    PubMed  CAS  Google Scholar 

  5. Lee HK, Kim SH, Cho JY, Yeon KM (1998) Uterine adenofibroma and adenosarcoma: CT and MR findings. J Comput Assist Tomogr 22(2):314–316

    Article  PubMed  CAS  Google Scholar 

  6. Clement PB, Scully RE (1990) Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol 21(4):363–381

    Article  PubMed  CAS  Google Scholar 

  7. Clement PB, Scully RE (1988) Uterine tumors with mixed epithelial and mesenchymal elements. Semin Diagn Pathol 5(2):199–222

    PubMed  CAS  Google Scholar 

  8. Bettaieb I, Mekni A, Bellil K, Haouet S, Bellil S, Kchir N, Chelly H, Zitouna M (2007) Endometrial adenofibroma: a rare entity. Arch Gynecol Obstet 275(3):191–193

    Article  PubMed  Google Scholar 

  9. Yavuz E, Tuzlali S, Iplikçi A, Ilhan R (2001) Adenomyolipoma of the uterus: a case report. Pathology 33(1):96–100

    Article  PubMed  CAS  Google Scholar 

  10. Sinkre P, Miller DS, Milchgrub S, Hameed A (2000) Adenomyofibroma of the endometrium with skeletal muscle differentiation. Int J Gynecol Pathol 19(3):280–283

    Article  PubMed  CAS  Google Scholar 

  11. Payne F, Rollason TP, Sivridis E (1992) Adenomyolipoma of the endometrium—a hamartoma? Histopathology 20:357–359

    Article  PubMed  CAS  Google Scholar 

  12. Ilhan R, Yavuz E, Iplikçi A, Tuzlali S (2001) Hamartomatous endocervical polyp with heterologous mesenchymal tissue. Pathol Int 51(4):305–307

    Article  PubMed  CAS  Google Scholar 

  13. Roth LM, Pride GL, Sharma HM (1976) Mullerian adenosarcoma of the uterine cervix with heterologous elements: a light and electron microscopic study. Cancer 37:1725–1736

    Article  PubMed  CAS  Google Scholar 

  14. Perone T, Carson LF, Dehner LP (1990) Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: a clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female. Med Pediatr Oncol 18:72–76

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Pamukkale University School of Medicine, Denizli, Turkey

    Metin Akbulut

  2. Department of Pathology, Ege University School of Medicine, Bornova, Izmir, Turkey

    Osman Zekioglu & Necmettin Ozdemir

  3. Department of Obstetrics and Gynaecology, Ege University School of Medicine, Izmir, Turkey

    Mustafa Cosan Terek

Authors
  1. Metin Akbulut
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  2. Osman Zekioglu
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  3. Mustafa Cosan Terek
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  4. Necmettin Ozdemir
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Corresponding author

Correspondence to Osman Zekioglu.

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Akbulut, M., Zekioglu, O., Terek, M.C. et al. Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor. Arch Gynecol Obstet 278, 283–286 (2008). https://doi.org/10.1007/s00404-008-0572-0

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  • DOI: https://doi.org/10.1007/s00404-008-0572-0

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