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Expression of insulin-like growth factor-1 receptors, Wilm’s tumor-1 protein, c-kit and p16 in primary fallopian tube carcinoma in diabetic patients

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Abstract

Background

Primary fallopian tube carcinoma (PFTC) represents less than 1% of all gynecological malignancies and its association with diabetes mellitus is seldom reported.

Cases

We report three cases of PFTC presented primarily as advanced ovarian cancer while the primary site totally silent. Two of them were diabetics and showed expression of insulin-like growth factor receptors, Wilm’s tumor protein-1, c-kit and P16. In all these cases there was neither clinical nor perioperative suspicion of PFTC and the first clinical diagnosis was ovarian carcinoma which was supported by positive cytology for ascitic fluid and raised serum level of CA125. The diagnosis was only established after histopathologic examination of serial sections of the whole fallopian tube since we were able to demonstrate the continuity between the invasive and the in situ components of PFTC in the lining epithelial layer of the fallopian tube.

Conclusion

The presence of malignant cells in the female pelvic organs without a mass should raise the possibility of primary fallopian tube carcinoma. Pre-operative diagnosis of PFTC is seldom made and most of the time the diagnosis is made after histopathological examination as in our cases. Diabetes mellitus can be a risk factor in the development of PFTC.

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Acknowledgments

The authors would like to acknowledge Prof. Ernest Adeghate in the Anatomy department, in the Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE, for his support during this work.

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Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O.Box 17666, Al Ain, United Arab Emirates

    Suhail AL-Salam

  2. Department of Pathology, Tawam Hospital, Al Ain, United Arab Emirates

    Mouied Alashari

  3. Department of Gynecology and Obstetrics, Tawam hospital, UAEU, P. O. Box 17666, Al-Ain, United Arab Emirates

    Saad Ghazal-Aswad

Authors
  1. Suhail AL-Salam
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  2. Mouied Alashari
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  3. Saad Ghazal-Aswad
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Correspondence to Suhail AL-Salam.

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AL-Salam, S., Alashari, M. & Ghazal-Aswad, S. Expression of insulin-like growth factor-1 receptors, Wilm’s tumor-1 protein, c-kit and p16 in primary fallopian tube carcinoma in diabetic patients. Arch Gynecol Obstet 277, 449–455 (2008). https://doi.org/10.1007/s00404-007-0494-2

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  • DOI: https://doi.org/10.1007/s00404-007-0494-2

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