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The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study

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Abstract

Objectives

The aim of the current study is to evaluate the differences in the rate of perinatal group B streptococcal vertical transmission between women who correctly underwent the CDC 2002 guidelines and women who did not.

Methods

Two study groups: women who correctly underwent the CDC 2002 guidelines (study group 1) and women who did not (study group 2). Intrapartum chemoprophylaxis (IC) was administered to all pregnant women identified as GBS carrier. All newborns received, in the first hour of life, a culture based screening for GBS colonization.

Results

One thousand six hundred and sixty nine women were enrolled in the study. The 2002 CDC guidelines were correctly applied in 1273 (76.3%) subjects. There was no early-onset GBS disease. No statistically significant difference in the total number of colonized newborns between study group 1 (4.1%) and study group 2 (3.3%) was found. When the analysis was limited to women with positive GBS screening, a significant difference (P < 0.001) was observed in the number of colonized newborns between mothers who received IC during at least 4 h (group 1; 3.7%) and those who received an IC during less than 4 h (group 1; 12.3%).

Conclusion

The accurate application of the 2002 CDC guidelines is strongly supported but, to furthermore reduce the risk for GBS colonization and sepsis in the newborns, it appears desirable to identify additional and new prevention strategies.

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Abbreviations

AAP:

American Academy of Pediatrics

ACOG:

American College of Obstetricians and Gynecologists

CDC:

Centers for Disease Control and Prevention

EOGBS:

Early-onset group B Streptococcus disease

g:

Gram

GBS:

Group B Streptococcus

IC:

Intrapartum chemoprophylaxis

mg:

Milligram

ml:

Milliliter

n:

Number

μg:

Microgram

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy

    Davide Lijoi, Elisa Di Capua, Simone Ferrero, Emanuela Mistrangelo, Sandra Morano & Nicola Ragni

  2. Department of Paediatrics, Genoa University, Genoa, Italy

    Alessandro Giannattasio

Authors
  1. Davide Lijoi
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  2. Elisa Di Capua
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  3. Simone Ferrero
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  4. Emanuela Mistrangelo
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  5. Alessandro Giannattasio
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  6. Sandra Morano
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  7. Nicola Ragni
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Correspondence to Davide Lijoi.

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Lijoi, D., Capua, E.D., Ferrero, S. et al. The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study. Arch Gynecol Obstet 275, 373–379 (2007). https://doi.org/10.1007/s00404-006-0263-7

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  • DOI: https://doi.org/10.1007/s00404-006-0263-7

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