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Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript



To evaluate the factors including the imaging findings and clinical and laboratory data that were useful for diagnosing mature cystic teratomas with malignant transformation.

Materials and methods

In 11 patients, we analyzed the imaging findings by the CT and MR focused on the soft tissue components for the following characteristics: size; the angle between the soft tissue components and the inner wall of the cyst (acute or obtuse); the configuration of the inner border (regular or irregular); and enhancement as well as tumor size. Clinical and laboratory data such as age, serum SCC, CA-125, CA 19-9, and AFP, were also determined.


In the analysis of the imaging findings, nine (82%) of all tumors had soft tissue components and eight (89%) of nine soft-tissue-containing tumors showed an obtuse angle between the soft tissue components and the inner wall of the cyst as well as enhancement. In nine (82%) of the study patients it was shown that the largest diameter of the tumor was larger than 9.9 cm and the patients were older than 45 years. In the results of the laboratory data, six (67%) of performed nine patients had a CA-125 elevation greater than 35 U/ml and three (75%) of performed four patients had a CA 19-9 elevation greater than 37 U/ml.


We suggest that preoperative diagnosis may be improved and available in cases of synthesized imaging findings with clinical and laboratory data.

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The authors thank Bonnie Hami, MA, Department of Radiology, University Hospitals Health System, Cleveland, OH, USA, for her editorial assistance in preparing the manuscript.

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Correspondence to Kyoung-Sik Cho.

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Park, S.B., Kim, J.K., Kim, KR. et al. Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data. Arch Gynecol Obstet 275, 25–31 (2007).

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