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Assessing the reproductive performance of men co-infected with HIV-1 and hepatitis C undergoing assisted reproduction

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Abstract

Objective: To assess the reproductive performance of men co-infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) undergoing assisted reproduction. Design: A retrospective analysis. Setting: University-based assisted reproductive technology (ART) center. Patients: We reviewed 217 consecutive ART cycles performed on 106 HIV-1 serodiscordant couples between August 1997 and March 2004, in which 28 men (26%) were seropositive for HCV and HIV-1 (group 1). Main outcome measures: Patient demographics and laboratory testing were compared to reproductive outcomes of men undergoing similar treatment but infected only with HIV-1 (group 2). Results: Co-infected men and their partners were of similar age as men infected only with HIV-1. Comparing group 1 to group 2, like values were noted for HIV-1 viral loads [1,993 ± 1,140 copies/ml (mean ± SE) vs. 1,659 ± 487 copies/ml]; CD4 counts (520 ± 98 vs. 604 ± 38 mm−3); and semen parameters. IVF performance and outcomes were similar, with fertilization rate (0.68 ± 0.03 vs. 0.71 ± 0.02); number of normally cleaving embryos (6.0 ± 0.5 vs. 5.3 ± 0.3); embryo implantation rate (0.27 ± 0.04 vs. 0.2 ± 0.02); and clinical pregnancy rate (40 vs. 29%). Although the male mortality rate was low in both groups, morbidity among co-infected men was significantly higher. Seven of 28 men (25%) had detectable HCV viral loads, and 14 (50%) had elevated liver function tests. Conclusion: Men co-infected with HCV and HIV-1 do reasonably well undergoing ART to prevent transmission of viruses to their partners and children.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 1790 Broadway, 2nd Floor, New York, NY, 10019, USA

    Micheline C. Chu, Joseph E. Pena, Gary S. Nakhuda, Melvin H. Thornton II & Mark V. Sauer

  2. Center for Women’s Reproductive Care, Columbia University, 1790 Broadway, 2nd Floor, New York, NY, 10019, USA

    Mark V. Sauer

Authors
  1. Micheline C. Chu
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  2. Joseph E. Pena
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  3. Gary S. Nakhuda
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  4. Melvin H. Thornton II
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  5. Mark V. Sauer
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Correspondence to Mark V. Sauer.

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Chu, M.C., Pena, J.E., Nakhuda, G.S. et al. Assessing the reproductive performance of men co-infected with HIV-1 and hepatitis C undergoing assisted reproduction. Arch Gynecol Obstet 274, 155–159 (2006). https://doi.org/10.1007/s00404-006-0164-9

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  • DOI: https://doi.org/10.1007/s00404-006-0164-9

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