Premature ovarian failure and pregnancy

Abstract

Setting: A case study of a woman with presumed premature menopause is presented. Results: After more than 4 years of premature menopause judged by subjective symptoms, bleeding history, and postmenopausal levels of gonadotropins, a woman conceived spontaneously 2 months after the start of hormone replacement treatment (HRT). Previously, ovarian stimulation with clomifen citrate had failed. She delivered prematurely due to preeclampsia and intrauterine growth retardation. Conclusions: Reviewing the literature finds that pregnancy is reported in woman with premature ovarian failure after the use of birth-control pills, HRT, ovarian stimulation, and in spontaneous cycles. Lack of oocyte donors and prohibition of the donor technique in some countries make other options valuable when optimal infertility treatment cannot be offered.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Amsterdam A, Tajima K, Frajese V, Seger R (2003) Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Mol Cell Endocrinol 202:77–80

    PubMed  CAS  Google Scholar 

  2. 2.

    Gücer F, Urdl W, Pieber D, Arikan MG, Giuliani A, Auner H (1997) Pregnancies in patients with premature ovarian failure. Clin Exp Obstet Gynecol 24:130–132

    PubMed  Google Scholar 

  3. 3.

    Kalantaridou SN, Nelson LM (2000) Premature ovarian failure is not premature menopause. Ann NY Acad Sci 900:393–402

    PubMed  CAS  Article  Google Scholar 

  4. 4.

    van Kasteren YM, von Blomberg M, Hoek A, de Koning C, Lambalk N, van Montfrans J et al (2000) Incipient ovarian failure and premature ovarian failure show the same immunological profile. Am J Reprod Immunol 43:359–366

    PubMed  Article  Google Scholar 

  5. 5.

    Vegetti W, Marozzi A, Manfredini E, Testa G, Alagna F, Nicolosi A et al (2000) Premature ovarian failure. Mol Cell Endocrinol 161(1–2):53–57

    PubMed  Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to F. F. Lauszus.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Vandborg, M., Lauszus, F.F. Premature ovarian failure and pregnancy. Arch Gynecol Obstet 273, 387–388 (2006). https://doi.org/10.1007/s00404-005-0096-9

Download citation

Keywords

  • Premature menopause
  • Ovarian stimulation
  • Pregnancy