Abstract
Objectives
Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women.
Study design
Twenty women (aged 43–60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy.
Results
Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67).
Conclusions
Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
The Writing Group for the PEPI Trial (1995) Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. J Am Med Assoc 273:199–208
Gambacciani M, Ciaponi M, Cappagli B (1997) Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. J Clin Endocrinol Metab 82:414–417
Soman V, Tamborlane W, De Franzo R (1978) Insulin binding and insulin sensitivity in isolated growth hormone deficiency. N Engl J Med 299:1025–1030
Marcuri N, Petraglia F, Genazzani A (1993) Hormonal treatments modulate pulsatile plasma growth hormone, gonadotrophin and osteocalcin levels in post-menopausal women. Maturitas 17:51–62
Stehling O, Doring H, Ertl J, Preibisch G, Schmidt I (1996) Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol 271:1770–1774
Considine RV, Sinha MK, Heiman ML (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292–295
Stephens TW, Basiski M, Bristow PK (1995) The role of neuropeptide Y in the antiobesity action of the obese gene mRNA in human obesity. J Clin Invest 95:2986–2988
Espeland MA, Stefanick MI, Krtiz-Silverstein D (1997) Effect of postmenopausal hormone therapy on body weight and waist and hip girths. J Clin Endocrinol Metab 82:1549–1556
Ongphiphadhanakul B, Chanprasertyothin S, Piaseu N, Chansirikanjana S, Puavilia G, Rajatanavin R (1998) Change in body weight after hormone replacement therapy in postmenopausal women is dependent on basal circulating leptin. Maturitas 30:283–288
Rymer JM (1998) The effects of tibolone. Gynecol Endocrinol 12:213–220
Ginsburg J, Prelevic G, Butler D, Okolo S (1995) Clinical experience with tibolone (Livial) over 8 years. Maturitas 21:71–76
Meeuwsen IB, Samson MM, Duursma SA, Verhaar HJ (2001) The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women. Endocrinology 142:4813–4817
Aloia JF, Vaswani A, Russo K, Sheehan M, Flaster E (1995) The influence of menopause and hormonal replacement therapy on body cell mass and body fat mass. Am J Obstet Gynecol 172:896–900
Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424–3427
Haffner SM, Mykkanen L (1997) Leptin concentrations in women in the San Antonia heart study: effect of menopausal status and postmenopausal hormone replacement therapy. Am J Epidemiol 146:581–585
Paolisso G, Rizzo MR, Mone CM, Tagliamonte MR, Gambardella A (1998) Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrinol 48:291–297
Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebach AH (1983) Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberration in premenopausal women. J Clin Endocrinol Metab 57:304–310
Helene B, Lavoie T, Taylor A, Sharpless J, Anderson E, Strauss C, Hall J (1999) Effects of short-term hormone replacement on serum leptin levels in postmenopausal women. J Clin Endocrinol Metab 51:415–422
Jolanda M, Elbers H, Valk G, Roo D, Snijders C (1999) Effects of administration of 17β-oestradiol on serum leptin levels in healthy postmenopausal women. J Clin Endocrinol Metab 51:449–454
Panidis DK, Rousso DH, Kourtis AI, Stergiopoulos KN, Mavromatidis GA, Katsikis IK (2001) The influence of tibolone upon serum leptin levels in post-menopausal women. Eur J Obstet Gynecol Reprod Biol 96:85–87
Wu Peng S, Rosenbaum M, Nicolson M, Chua SC, Leibel RL (1999) Effects of exogenous gonadal steroids on leptin homeostasis in rats. Obes Res 42:237–240
Tena-Sempere M, Pinilla L, Gonzalez LC, Dieguez C, Casanueva FF, Agnilar E (1999) Leptin inhibits testosterone secretion from adult rat testis in vitro. J Endocrinol 161:211–218
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gol, M., Ozsener, S., Sendag, F. et al. Does tibolone affect serum leptin levels and body weight in postmenopausal women?. Arch Gynecol Obstet 272, 127–130 (2005). https://doi.org/10.1007/s00404-004-0686-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-004-0686-y