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Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results

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Abstract

Purpose

Mastectomy without axillary dissection should be the standard treatment in patients with malignant form of cystosarcoma phyllodes. The role of postoperative radiotherapy and chemotherapy remains to be fully established. We evaluate treatment results in a group of patients with cystosarcoma phyllodes (CP) treated at our Institute.

Patients and methods

In this report we analyze treatment outcome in 25 patients with malignant cystosarcoma phyllodes treated at Masaryk Memorial Cancer Institute between 1970 and 1995. Mean tumor size was 10 cm in diameter. All patients underwent surgery. Subsequently, 17 patients (68%) received radiotherapy on the breast or chest wall.

Results

Median follow-up was 139.5 months. Local recurrence was observed in 16% of all patients and all patients with local recurrence died. Time to local relapse after surgery was 4–11 months. Distant metastases occurred in 5 patients. All patients with local recurrence had distant metastases. Dissemination occurred 3–19 months after local recurrence. Five-year survival of all patients was 80%.

Conclusion

A specific protocol for the treatment of cystosarcoma phyllodes is missing, probably due to rarity of the disease. The treatment of local recurrent disease remains unsuccessful in most CP patients. We recommend postoperative irradiation on the chest wall in patients with malignant form of CP, because adjuvant radiotherapy decreased the incidence of local relapse in our group of patients.

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References

  1. Alam I, Awad ZT, Given HF (2003) Cystosarcoma phyllodes of the breast: a clinicopathological study of 11 cases. Ir Med J 96:179–180

    CAS  PubMed  Google Scholar 

  2. Chaney AW, Pollack A, McNeese MD, Zagars GK (1998) Adjuvant radiotherapy for phyllodes tumor of breast. Radiat Oncol Invest 6:264–267

    Article  CAS  Google Scholar 

  3. Chaney AW, Pollack A, McNeese MD et al (2000) Primary treatment of cystosarcoma phyllodes of the breast. Cancer 89:1502–1511

    Article  PubMed  Google Scholar 

  4. Cohn-Cedemark G, Rutquist LE, Rosendahl I et al (1991) Prognostic factors in Cystosarcoma phylloides: a clinicopathological study of 77 patients. Cancer 68:2017–22

    PubMed  Google Scholar 

  5. De Roos WK, Kaye P, Dent DM (1999) Factors leading to local recurrence or death after surgical resection of phyllodes tumours of the breast. Br J Surg 86:396–399

    PubMed  Google Scholar 

  6. Dietz R (1990) Das Cystosarkoma phylloides malignum. Strahlenther Onkol 167:292–294

    Google Scholar 

  7. Eich P, Diederich S, Eich H et al (2000) Diagnostic radiation oncology: malignant cystosarcoma phylloides. Strahlenther Onkol 176:192–195

    Article  CAS  PubMed  Google Scholar 

  8. Geisler DP, Boyle MJ, Malnar KF et al (2000) Phyllodes tumours of the breast: a review of 32 cases. Am Surg 66:360–366

    CAS  PubMed  Google Scholar 

  9. Hawkins RE, Schofield JB, Fisher C et al (1992) The clinical and histologic criteria that predict metastases from cystosarcoma phylloides. Cancer 69:141–147

    CAS  PubMed  Google Scholar 

  10. Iau PT, Lim TC, Png DJ, Tan WT (1998) Phyllodes tumour: an update of 40 cases. Ann Acad Med Singapore 27:200–203

    CAS  PubMed  Google Scholar 

  11. Khan SA, Badve S (2001) Phyllodes tumors of the breast. Curr Treat Options Oncol 2:139–147

    CAS  PubMed  Google Scholar 

  12. Kok KYY, Telesinghe PU, Yapp SKS (2001) Treatment and outcome of cystosarcoma phylloides in Brunei. J R Coll Surg Edinb 46:198–201

    CAS  PubMed  Google Scholar 

  13. Mallebre B, Ebert A, Perez-Canto A et al (1996) Cystosarcoma phylloides of the breast. A retrospective analysis of 12 cases. Geburtshilfe Frauenheilkd 56:35–40

    CAS  PubMed  Google Scholar 

  14. Pandey M, Mathew A, Kattoor J et al (2001) Malignant phyllodes tumor. Breast J 7:411–416

    Article  CAS  PubMed  Google Scholar 

  15. Perez CA, Brady LW et al (1997) Principles and practice of radiation oncology, 3rd edn. Lippincott-Raven, Philadelphia

  16. Pietruszka M, Barnes L (1978) Cystosarcoma phylloides: a clinicopathologic analysis of 42 cases. Cancer 41:1974–1983

    CAS  PubMed  Google Scholar 

  17. Reinfuss M, Mitus J, Stelmach A (1995) Phyllodes tumor of the breast. Strahlenther Onkol 171:5–11

    CAS  PubMed  Google Scholar 

  18. Treves N, Sunderland D (1951) Cystosarcoma phylloides of the breast: a malignant and benign tumor. Cancer 1286–1332

    Google Scholar 

  19. Vorherr H, Vorherr UF, Kutvirt DM et al (1985) Cystosarcoma phyllodes: epidemiology, pathohistology, pathobiology, diagnosis, therapy and survival. Arch Gynecol Obstet 236:173–181

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Žlutý kopec 7, 656 53, Brno, Czech Republic

    Renata Soumarová, Zuzana Šeneklová, Hana Horová, Hana Vojkovská, Jana Růžičková & Barbara Ježková

  2. Department of Applied Mathematics, Masaryk University, Brno, Czech Republic

    Ivana Horová

Authors
  1. Renata Soumarová
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  2. Zuzana Šeneklová
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  3. Hana Horová
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  4. Hana Vojkovská
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  5. Ivana Horová
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  6. Marie Budíková
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  7. Jana Růžičková
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  8. Barbara Ježková
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Correspondence to Renata Soumarová.

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Soumarová, R., Šeneklová, Z., Horová, H. et al. Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results. Arch Gynecol Obstet 269, 278–281 (2004). https://doi.org/10.1007/s00404-003-0593-7

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  • DOI: https://doi.org/10.1007/s00404-003-0593-7

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