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The effect of mid-luteal estradiol level on the outcome of ICSI-ET cycles

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Abstract

Methods

We investigated if mid-luteal estradiol levels could predict the outcome in intracytoplasmic sperm injection embryo transfer (ICSI-ET) cycles (n=231). Pregnant and non-pregnant women were compared regarding their peak estradiol levels on human chorionic gonadotropin (hCG) injection day, and mid-luteal estradiol levels on the 7th day following oocyte recovery. Pregnancy rates of the groups that were designed according to the "peak/mid-luteal estradiol level" and the mid-luteal estradiol levels were also compared.

Results

Peak and mid-luteal estradiol levels in pregnant women were higher than in non-pregnant women in all patients, although the difference between peak and mid-luteal estradiol levels were similar in pregnant and non-pregnants. Pregnant women had higher mid-luteal estradiol levels in good responders, but the peak estradiol levels of pregnant and non-pregnant women were similar. In poor responders, pregnant and non-pregnant women were similar with respect to peak and mid-luteal estradiol levels. Both in all patients and good responders, women with mid-luteal estradiol levels <200 pg/ml had lower pregnancy rates than those with >2,000 pg/ml. Peak/mid-luteal estradiol ratios of pregnant and non-pregnant women were not significantly different in all patients, good responders and poor responders; although a tendency for a lower ratio in pregnants was encountered in good responders. Pregnancy rates of the groups according to the "peak/mid-luteal estradiol ratio" were similar; in all patients, good responders and poor responders.

Conclusion

A relation between the mid-luteal estradiol level and the outcome is encountered only in good responders.

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Authors and Affiliations

  1. IVF Department, Ozel Ege Tup Bebek Merkezi, 1418 sokak No: 10, 35230, Kahramanlar-Izmir, Turkey

    Erdal Aktan, Kaan Bozkurt & Dilek Ozer

  2. Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey

    Sait Yucebilgin, Nedim Karadadas & Onur Bilgin

Authors
  1. Erdal Aktan
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  2. Kaan Bozkurt
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  3. Dilek Ozer
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  4. Sait Yucebilgin
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  5. Nedim Karadadas
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  6. Onur Bilgin
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Correspondence to Erdal Aktan.

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Aktan, E., Bozkurt, K., Ozer, D. et al. The effect of mid-luteal estradiol level on the outcome of ICSI-ET cycles. Arch Gynecol Obstet 269, 134–138 (2004). https://doi.org/10.1007/s00404-003-0533-6

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  • DOI: https://doi.org/10.1007/s00404-003-0533-6

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