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The effect of metformin treatment to ovarian response in cases with PCOS

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Abstract

Objective.

To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients.

Design.

Randomized prospective study.

Setting.

Zeynep Kamil Hospital IVF Center.

Patients.

Thirty-two female PCOS patients with clomiphene citrate resistance.

Interventions.

Test group A received 2×850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B.

Main outcome measures.

Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with ≥16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate.

Results.

The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group.

Conclusions.

Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.

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Correspondence to Cem Ficicioglu.

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Tasdemir, S., Ficicioglu, C., Yalti, S. et al. The effect of metformin treatment to ovarian response in cases with PCOS. Arch Gynecol Obstet 269, 121–124 (2004). https://doi.org/10.1007/s00404-002-0447-8

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  • DOI: https://doi.org/10.1007/s00404-002-0447-8

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