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Bowenoid papulosis of the vulva—immunotherapeutical approach with topical imiquimod

  • Case Report
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Abstract

Introduction.

Bowenoid papulosis is a characteristic lesion of the ano-genital region and represents a form of squamous cell carcinoma in situ, very often associated to the oncogenic high-risk human papilloma virus (HPV) types 16, 18, 31 and 33. Therapies applied so far, in general, show high rates of relapse, and patients complain of pruritus and pain. Imiquimod cream is a topical immune response modifier with indirect antiviral and antitumor effects through the stimulation of local cytokine production and cell-mediated immune response.

Case report.

In the present paper we report on the topical application of imiquimod cream in a woman with a high-risk HPV-associated vulvar intraepithelial neoplasia grade III (VIN III) of the vulva.

Discussion

In addition a review of the literature is given.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Bonn School of Medicine, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany

    O. N. Richter, M. Kupka & U. Ulrich

  2. Department of Dermatology, University of Bonn School of Medicine, Sigmund-Freud-Strasse 25, 53105 , Bonn, Germany

    W. Petrow

  3. Department of Pathology, University of Bonn School of Medicine, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany

    E. Wardelmann

Authors
  1. O. N. Richter
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  2. W. Petrow
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  3. E. Wardelmann
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  4. C. Dorn
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  5. M. Kupka
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  6. U. Ulrich
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Correspondence to O. N. Richter.

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Richter, O.N., Petrow, W., Wardelmann, E. et al. Bowenoid papulosis of the vulva—immunotherapeutical approach with topical imiquimod. Arch Gynecol Obstet 268, 333–336 (2003). https://doi.org/10.1007/s00404-002-0385-5

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  • DOI: https://doi.org/10.1007/s00404-002-0385-5

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