Abstract
Introduction
The vagina as a primary site of malignant lymphoma in woman is extremely rare.
Case report
We report here a 30-year-old patient with a primary vaginal non-Hodgkin's lymphoma stage IEA, follicular large cell of B lineage, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free survival of 28 months.
Conclusion
Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women chemotherapy should be considered to preserve fertility, as well as quality of life.
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References
Bitran JD, Kinzie J, Sweet DL, Variakojis D, Griem ML, Golomb HM, Miller JB, Oetzel N, Ultmann JE (1977) Survival of patients with localized histiocytic lymphoma. Cancer 39:342–346
Chorlton I, Karnei RF, King FM, Norris HJ (1974) Primary malignant reticuloendothelial disease involving the vagina, cervix, and corpus uteri. Obstet Gynecol 44:735–748
Ferry JA, Young RH (1997) Malignant lymphoma of the genitourinary tract. Curr Diagn Pathol 4:145–169
Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260
Harns NI, Scully RE (1984) Malignant lymphoma and granulocytic sarcoma of the uterus and vagina, a clinicopathological analysis of 27 cases. Cancer 53:2530–2545
Jenkins N, Husband J, Sellars N, Gore M (1997) MRI in primary non-Hodgkin's lymphoma of the vagina associated with a uterine congenital anomaly. Br J Radiol 70:219–222
Kitamura K, Takaku F (1990) Pirarubicin, a novel derivative of doxorubicin, THPCOP therapy for non-Hodgkin's lymphoma in the elderly. Am J Clin Oncol 13 [Suppl 1]:S15–S19
Mann R, Roberts WS, Gunasakeran S, Tralins A (1987) Primary lymphoma of the uterine cervix. Gynecol Oncol 26:127–134
McNicholas MM, Fennelly JJ, MacErlaine DP (1994) Imaging of primary vaginal lymphoma. Clin Radiol 49:130–132
Muntz HG, Ferry JA, Flynn D, Fuller AF, Tarraza HM (1991) Stage IE primary malignant lymphomas of the uterine cervix. Cancer 68:2023–2032
Nasu K, Yoshimatsu J, Urata K, Miyakawa I (1998) A case of primary non-Hodgkin's lymphoma of the uterine cervix treated by combination chemotherapy (THP-COP). J Obstet Gynaecol Res 24:157–160
Perren T, Farrant M, McCarthy K, Harper P, Wiltshaw E (1992) Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature. Gynecol Oncol 44:87–95
Prevot S, Hugol D, Audouin J, Diebold J, Truc JB, Decroix Y, Poitout P (1992) Primary non-Hodgkin's malignant lymphoma of the vagina. Report of 3 cases with review of the literature. Pathol Res Pract 188:78–85
Raspagliesi F, Ditto A, Fontanelli R, Gallino G, Massone PB, De Galo G (2000) Primary non-Hodgkin's lymphoma -of the vagina. Haematologica 85:666–667
Rassiga A (1980) Advances in adult non-Hodgkin's lymphoma. Arch Intern Med 140:1647–1651
Vang R, Medeiros LJ, Ha CS, Deavers M (2000) Non-Hodgkin's lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol 13:19–28
Vang R, Medeiros LJ, Silva EG, Gershenson DM, Deavers M (2000) Non-Hodgkin's lymphoma involving the vagina: a clinicopathologic analysis of 14 patients. Am J Surg Pathol 24:719–725
Yokoyama Y, Sato S, Xiao YH, Tanaka K, Maruyama H, Saito Y (2001) Primary non-Hodgkin's lymphoma of the uterine cervix. Arch Gynecol Obstet 265:108–111
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Engin, H., Türker, A., Abali, H. et al. Successful treatment of primary non-Hodgkin's lymphoma of the vagina with chemotherapy. Arch Gynecol Obstet 269, 208–210 (2004). https://doi.org/10.1007/s00404-002-0350-3
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DOI: https://doi.org/10.1007/s00404-002-0350-3