Abstract The objective was to test the hypothesis that there is a correlation between thinning of the skin and bone in patients on chronic oral glucocorticoids (GCs). This was a one-time cross-sectional analysis performed in an academic referral center. The study group consisted of 14 patients on GCs for a variety of disorders, including dermatomyositis, pemphigus vulgaris, pyoderma gangrenosum, and urticarial vasculitis. Skin thickness was compared with that of 24 sex- and age-matched controls. The main outcome measures were the bone density of the lumbar spine (L2–L4) and the skin thickness. The skin thickness (mm, mean ± SEM) in GC-treated (n = 7) vs unmedicated age-matched Caucasian women (n = 20) was 0.84 ± 0.04 vs 1.02 ± 0.04 (t = 3.07, P < 0.01) in the upper arm, 1.13 ± 0.09 vs 1.49 ± 0.05 (t = 3.65, P < 0.002) in the dorsal forearm, and 0.96 ± 0.07 vs 1.17 ± 0.02 (t = 2.92, P < 0.01) in the ventral forearm. L2–L4 bone densities averaged 106 ± 2% in the GC-treated female patients relative to the age and sex-matched controls. There was no correlation between skin thickness and bone density. In GC-treated (n = 4) vs unmedicated Caucasian men matched for age (n = 4), skin thickness was 1.09 ± 0.4 vs 1.33 ± 0.05 (t = 3.51, P < 0.02) in the upper arm, but was not significantly different at the two forearm sites. No correlation between skin thickness and bone density was observed. The level of type I procollagen mRNA in skin from three GC-treated patients was 45% of the value in three age-matched controls. In conclusion, GCs cause statistically significant thinning of skin independently of the effects on bone.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 19 November 1997
Rights and permissions
About this article
Cite this article
Werth, V., Kligman, A., Shi, X. et al. Lack of correlation of skin thickness with bone density in patients receiving chronic glucocorticoid. Arch Dermatol Res 290, 388–393 (1998). https://doi.org/10.1007/s004030050322
Issue Date:
DOI: https://doi.org/10.1007/s004030050322