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Benefits and challenges of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies: a systematic review

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Abstract

Mohs micrographic surgery is the gold standard for treating many types of skin cancer, particularly skin cancers of high-risk areas such as the face, genitalia, and digits, due to its tissue-sparing technique and low recurrence rates. The use of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies has yet to be explored in a systematic review. The authors sought to assess outcomes including recurrence rates of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies. PubMed was searched for the use of Mohs micrographic surgery in types of human papilloma virus-associated cutaneous malignancies. After application of exclusion and inclusion criteria, 33 articles were included. 700 cases from 33 studies were included. Overall recurrence rate following Mohs micrographic surgery was 39/478 (8.2%) at a mean follow-up time of 51.5 months. Recurrence rate for nail unit/digit squamous cell carcinoma was 10/103 (9.7%) at mean follow-up of 47.6 months. Recurrence rate for penile squamous cell carcinoma was 15/181 (8.3%) at mean follow-up of 45.9 months. Recurrence rate for Bowen’s disease in extragenital areas was 11/189 (5.9%) at mean follow-up of 59.7 months. Patients overall reported satisfactory functional and cosmetic results. Mohs micrographic surgery demonstrates low recurrence rates and excellent functional and cosmetic outcomes in the treatment of human papilloma virus-associated cutaneous malignancies.

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Data availability

No datasets were generated or analysed during the current study.

Abbreviations

MMS:

Mohs micrographic surgery

HPV:

Human papilloma virus

SCC:

Squamous cell carcinoma

BD:

Bowen’s disease

SCCIS:

Squamous cell carcinoma in situ

DNA:

Deoxyribonucleic acid

UV:

Ultraviolet

WLE:

Wide local excision

EMPD:

Extramammary Paget disease

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Authors and Affiliations

  1. Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA

    Hannah R. Riva & Teresa Yoon

  2. Department of Dermatology, Baylor Scott & White Medical Center, Temple, TX, USA

    Mojahed Mohammad K. Shalabi

  3. Galaria Plastic Surgery & Dermatology, Chantilly, VA, USA

    Aamir Hussain

  4. Department of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, NY, USA

    Amor Khachemoune

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  4. Aamir Hussain
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Contributions

H.R. and T.Y. wrote the main manuscript text and prepared the figure and tables. M.M.K.S. edited the manuscript. A.H. and A.K. supervised the project and reviewed the manuscript. All authors reviewed and approved the manuscript.

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Correspondence to Amor Khachemoune.

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Riva, H.R., Yoon, T., Mohammad K. Shalabi, M. et al. Benefits and challenges of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies: a systematic review. Arch Dermatol Res 316, 617 (2024). https://doi.org/10.1007/s00403-024-03364-8

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