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Association of alopecia areata and ischemic heart disease and cerebrovascular in U.S. adults: an all of us database study

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Abbreviations

AA:

Alopecia Areata

CVD:

Cardiovascular diseases

CeVD:

Cerebrovascular diseases

ICD-10-CM:

International Classification of Diseases, 10th Revision

IHD:

Ischemic heart diseases

OR:

Odds ratio

US:

United States

References

  1. Glickman JW, Dubin C, Renert-Yuval Y et al (2021) Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation. J Am Acad Dermatol 84(2):370–380

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  2. Shin J-W, Kang T, Lee JS et al (2020) Time-Dependent risk of Acute myocardial infarction in patients with Alopecia Areata in Korea. JAMA Dermatol 156(7):763–771

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  3. All of Us Data Snapshots. National Institutes of Health (2023) Updated February 20. https://www.researchallofus.org/data-tools/data-snapshots/. Accessed February 21

  4. O’Hagan R, Caldas SA, Correa da Rosa JM et al (2023) Alopecia Areata is associated with increased genetic risk of myocardial infarction: a mendelian randomization study. J Eur Acad Dermatol Venereol

  5. Joseph P, Leong D, McKee M et al (2017) Reducing the Global Burden of Cardiovascular Disease, Part 1: the epidemiology and risk factors. Circ Res 121(6):677–694

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Acknowledgements

The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

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Authors and Affiliations

  1. Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, New York, NY, 10029, US

    Stella Caldas, Angel D Pagan, Juliana Pulsinelli, Joel Correa da Rosa, Seungyeon Jung, Divija Sharma, Jonas A Adalsteinsson & Benjamin Ungar

  2. George Washington University School of Medicine, Washington, DC, US

    Stella Caldas

  3. Ponce Health Sciences University School of Medicine, Ponce, PR, US

    Angel D Pagan

  4. Vanderbilt University School of Medicine, Nashville, TN, US

    Seungyeon Jung

  5. University of Louisville School of Medicine, Louisville, KY, US

    Divija Sharma

Authors
  1. Stella Caldas
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  2. Angel D Pagan
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  3. Juliana Pulsinelli
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  4. Joel Correa da Rosa
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  5. Seungyeon Jung
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  6. Divija Sharma
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  7. Jonas A Adalsteinsson
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  8. Benjamin Ungar
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Contributions

SC, AP, SJ, DS wrote the main manuscript text and prepared the tables, JP and JCDR performed the analysis, JAA and BU oversaw and supervised analysis and manuscript preparation. All authors reviewed the manuscript.

Corresponding author

Correspondence to Benjamin Ungar.

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Conflict of interest

BU is an employee of Mount Sinai and has received research funds (grants paid to the institution) from: Incyte, Rapt Therapeutics, and Pfizer. He is also a consultant for Arcutis Biotherapeutics, Bristol Myers Squibb, Castle Biosciences, Fresenius Kabi, Galderma, Pfizer, Sanofi, and UCB. JCDR is an employee of Mount Sinai. JAA is an employee of Mount Sinai. The rest of the authors declare no relevant conflicts of interest.

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Caldas, S., Pagan, A.D., Pulsinelli, J. et al. Association of alopecia areata and ischemic heart disease and cerebrovascular in U.S. adults: an all of us database study. Arch Dermatol Res 316, 202 (2024). https://doi.org/10.1007/s00403-024-02959-5

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  • DOI: https://doi.org/10.1007/s00403-024-02959-5

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