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Study of original B cells producing pathogenic IgG and IgA autoantibodies in anti-BP180-type mucous membrane pemphigoid

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Fig. 1
Fig. 2

Data availability

The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request. Data are located in controlled access data storage at Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine.

Abbreviations

MMP:

Mucous membrane pemphigoid

CSR:

Immunoglobulin class switch recombination

RP:

Recombinant protein

GST:

Glutathione-S-transferase

MW:

Molecular weight

References

  1. Chan LS, Ahmed AR, Anhalt GJ, Bernauer W, Cooper KD, Elder MJ et al (2002) The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol 138:370–379. https://doi.org/10.1001/archderm.138.3.370

    Article  PubMed  Google Scholar 

  2. Hayakawa T, Furumura M, Fukano H, Li X, Ishii N, Hamada T et al (2014) Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing. Oral Surg Oral Med Oral Pathol Oral Radiol 117:483–496. https://doi.org/10.1016/j.oooo.2013.12.402

    Article  PubMed  Google Scholar 

  3. Yasukochi A, Teye K, Ishii N, Hashimoto T (2016) Clinical and immunological studies of 332 Japanese patients tentatively diagnosed as anti-BP180-type mucous membrane pemphigoid: a novel BP180 C-terminal domain enzyme-linked immunosorbent assay. Acta Derm Venereol 96:762–767. https://doi.org/10.2340/00015555-2407

    Article  CAS  PubMed  Google Scholar 

  4. Nie Z, Hashimoto T (1999) IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180. J Invest Dermatol 112:254–255. https://doi.org/10.1046/j.1523-1747.1999.00501.x

    Article  CAS  PubMed  Google Scholar 

  5. Honjo T, Kinoshita K, Muramatsu M (2002) Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu Rev Immunol 20:165–196. https://doi.org/10.1146/annurev.immunol.20.090501.112049

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

RP production was guided by Ms. Kira and Ms. Yabunaka at the Research Support Platform, Graduate School of Medicine, Osaka Metropolitan University. We are grateful to Ms. Noriko Okabayashi and Ms. Yoko Mukaoku for their secretarial work. We thank all patients for their participation. This study was supported by JSPS KAKENHI Grant (Grant-in-Aid for Scientific Research (C) Number 18K08275) to Takashi Hashimoto, and by “Research on Measures for Intractable Diseases” from the Ministry of Health, Labor and Welfare Project to Takashi Hashimoto.

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Authors and Affiliations

  1. Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno, Osaka, 545-8585, Japan

    Daisuke Hayashi, Takashi Hashimoto, Mako Mine & Daisuke Tsuruta

  2. Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan

    Norito Ishii & Atsunari Tsuchisaka

  3. Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-Ku, Tokyo, 153-8902, Japan

    Koji Hashimoto

Authors
  1. Daisuke Hayashi
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  2. Takashi Hashimoto
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  3. Mako Mine
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  4. Norito Ishii
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  5. Koji Hashimoto
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  6. Atsunari Tsuchisaka
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  7. Daisuke Tsuruta
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Contributions

D Hayashi performed the experiments, analysed the data and wrote the manuscript. T Hashimoto contributed to the conception and design of the study and the supervision of the research and revision of the manuscript. M Mine performed the experiments. N Ishii collected patients' clinical information and samples. K Hashimoto contributed to the conception of the study. A Tsuchisaka contributed to the experiment guidance. D Tsuruta supervised the study. All authors have read and approved the submitted manuscript.

Corresponding author

Correspondence to Takashi Hashimoto.

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Hayashi, D., Hashimoto, T., Mine, M. et al. Study of original B cells producing pathogenic IgG and IgA autoantibodies in anti-BP180-type mucous membrane pemphigoid. Arch Dermatol Res 316, 169 (2024). https://doi.org/10.1007/s00403-024-02915-3

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  • DOI: https://doi.org/10.1007/s00403-024-02915-3

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