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Pediatric primary cutaneous anaplastic large-cell lymphoma with associated hypovitaminosis D

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Abstract

CD30+ lymphoproliferative diseases (LPDs) are relatively uncommon in the general population, especially in children. Distinguishing between the two main CD30+ LPDs, lymphomatoid papulosis and cutaneous anaplastic large-cell lymphoma is crucial, as the latter requires different treatment and systemic malignancy workup. We outline an uncommon presentation of a primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) accompanied by hypovitaminosis D in a young Hispanic child and a holistic approach to treatment. While baseline testing of vitamin D levels in patients with cutaneous lymphoma and LPDs is not yet the standard in dermatology, it is being increasingly performed by other specialties who care for solid tumor and hematologic malignancies, since low levels can portend poorer prognosis and outcomes. Although there are no precise treatment guidelines for pediatric PC-ALCL located in cosmetically sensitive areas, a minimally invasive therapeutic program comprised of shave removal, topical steroids, and correction of a potentially disease modifying comorbidity (hypovitaminosis D if present) offers a comprehensive approach.

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Data availability

No datasets were generated or analysed during the current study.

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Funding

No funding was received for the preparation of this manuscript. We thank Michael Morgan, MD and Korpath LLC for providing complimentary pathology services for this patient.

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Authors and Affiliations

  1. Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Blvd, Bradenton, FL, 34211, USA

    Eleanor Tung-Hahn & Valerie Mogilevskiy

  2. Colgate University, Hamilton, NY, USA

    Ellie Black

  3. Pathology, University of South Florida College of Medicine, Tampa, FL, USA

    Michael Morgan

  4. Dermatology, Michigan State University College of Medicine, Lansing, MI, USA

    Michael Morgan

  5. KorPath, LLC, Tampa, FL, USA

    Michael Morgan

  6. Dermatology, University of Central Florida College of Medicine, Orlando, FL, USA

    Rebecca Tung

  7. Florida Dermatology and Skin Cancer Centers, Winter Haven, FL, USA

    Rebecca Tung

Authors
  1. Eleanor Tung-Hahn
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  2. Valerie Mogilevskiy
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  3. Ellie Black
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  4. Michael Morgan
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  5. Rebecca Tung
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Contributions

ETH conception and design, writing and editing of manuscript, data collection, data analysis and interpretation. VM writing and editing of manuscript, data collection, data analysis and interpretation. EB writing and editing of the manuscript. MM data collection, data analysis and interpretation, editing of manuscript. RT data collection, data analysis and interpretation, editing of manuscript.

Corresponding author

Correspondence to Eleanor Tung-Hahn.

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The authors declare no conflicts of interest to disclose relevant to the content of this manuscript.

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The patient’s parent provided informed written consent for photographs present in the manuscript.

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The authors confirm that any aspect of the work covered in this manuscript that has involved human patients has been conducted with the ethical approval of all relevant bodies.

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Tung-Hahn, E., Mogilevskiy, V., Black, E. et al. Pediatric primary cutaneous anaplastic large-cell lymphoma with associated hypovitaminosis D. Arch Dermatol Res 316, 50 (2024). https://doi.org/10.1007/s00403-023-02790-4

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  • DOI: https://doi.org/10.1007/s00403-023-02790-4

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