Abstract
Common medical events may be associated with decreased immunologic activity and dysregulation of functional epithelial and neuronal tissues caused by growth factors and vesicle secretion by stem and somatic cells. Systemic injection of MSCs has been shown to reduce the immune response mainly through paracrine mechanisms, but some points related to the possibility of adverse events and side effects should be clarified. Flow cytometry for at least 20 cell markers is crucial to assess cell senescence and overall cell viability. Thus, adverse events and unreasonable expectations from cell therapy can be prevented. We believe that by using the precision cell phenotyping kits in clinical trials, many undesirable side effects related to misconceptions about the origin of the cells can be avoided.
Data availability
The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
References
Ramos-Gonzalez G, Salazar L, Wittig O et al (2023) The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing. Arch Dermatol Res 315:815–823. https://doi.org/10.1007/s00403-022-02451-y
Viswanathan S, Shi Y, Galipeau J et al (2019) Mesenchymal stem versus stromal cells: International Society for Cell and Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy 21(10):1019–1024. https://doi.org/10.1016/j.jcyt.2019.08.002
Maksimova NV, Michenko AV, Krasilnikova OA et al (2022) Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period. BioImpacts 12(1):51–55. https://doi.org/10.34172/bi.2021.22167
Baranovskii DS, Klabukov ID, Arguchinskaya NV et al (2022) Adverse events, side effects and complications in mesenchymal stromal cell-based therapies. Stem Cell Investig 9:7. https://doi.org/10.21037/sci-2022-025
Funding
This research received no external funding.
Author information
Authors and Affiliations
Contributions
IK, EY, DB wrote the main manuscript text. All authors reviewed and approved the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Klabukov, I., Yatsenko, E. & Baranovskii, D. The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing: ignoring the possibility of adverse events and side effects could compromise study results. Arch Dermatol Res 316, 35 (2024). https://doi.org/10.1007/s00403-023-02783-3
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00403-023-02783-3