Skip to main content

Advertisement

SpringerLink
Log in

Increased d-dimer and fibrin degradation product levels as potential indicators for evaluating infection-related acute urticaria: a case-case–control study

  • ORIGINAL PAPER
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

About 20% of world population suffer from acute urticaria at some stage in their lives. Recent studies showed coagulation dysfunction in chronic urticaria. The involvement of coagulation changes in acute urticaria remains unclear. Fifty-eight acute urticaria patients were enrolled in this study and divided into two groups (referred to throughout as infection-related and infection-unrelated acute urticaria). The routine laboratory parameters including coagulation tests between the two groups were compared. The correlation between coagulation tests and CRP at acute phase was also assessed. Dynamic change of routine coagulation test results at acute phase and resolving phase was compared. The potential performance of coagulation for infection indication was tested. We found d-dimer, fibrin degradation product (FDP), and fibrinogen (Fg) increased in the acute phase of infection-related acute urticaria patients. d-dimer, FDP, Fg, and APTT are positively correlated with CRP in the acute phase. d-dimer and FDP decreased in the resolving phase of infection-related acute urticaria patients. Higher d-dimer (> 0.48 mg/L) and FDP (> 3.84 mg/L) may indicate infection-related acute urticaria. In conclusion, in acute urticaria with low venous thromboembolism risk, d-dimer level and dynamic change can be potentially used for the infection-related clinical practice management.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B et al (2018) The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 73:1393–1414

    Article  CAS  PubMed  Google Scholar 

  2. Peck G, Hashim MJ, Shaughnessy C, Muddasani S, Elsayed NA, Fleischer AB Jr (2021) Global epidemiology of urticaria: increasing burden among children, females and low-income regions. Acta Derm Venereol 101:adv00433

    Article  PubMed  Google Scholar 

  3. Cugno M, Asero R, Tedeschi A, Lazzari R, Marzano AV (2012) Inflammation and coagulation in urticaria and angioedema. Curr Vasc Pharmacol 10:653–658

    Article  CAS  PubMed  Google Scholar 

  4. Sakurai M, Oba M, Matsumoto K, Tokura Y, Furukawa F, Takigawa M (2000) Acute infectious urticaria: clinical and laboratory analysis in nineteen patients. J Dermatol 27:87–93

    Article  CAS  PubMed  Google Scholar 

  5. Takahashi T, Minami S, Teramura K, Tanaka T, Fujimoto N (2018) Four cases of acute infectious urticaria showing significant elevation of plasma D-dimer level. J Dermatol 45:1013–1016

    Article  PubMed  Google Scholar 

  6. Hagiwara S, Oshima K, Aoki M, Murata M, Ishihara K, Kaneko M et al (2013) Usefulness of fibrin degradation products and d-dimer levels as biomarkers that reflect the severity of trauma. J Trauma Acute Care 74:1275–1278

    Article  CAS  Google Scholar 

  7. Ghazanfar MN, Thomsen SF (2018) D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review. Eur J Dermatol 28:731–735

    Article  CAS  PubMed  Google Scholar 

  8. Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A et al (2004) Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 8:R82-90

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tripodi A (2011) D-dimer testing in laboratory practice. Clin Chem 57:1256–1262

    Article  CAS  PubMed  Google Scholar 

  10. Dumoulin EN, Fiers L, Devreese KMJ (2016) Investigation of sensitivity for coagulation factor deficiency in APTT and PT: how to perform it? Clin Chem Lab Med 54:e169–e172

    Article  CAS  Google Scholar 

  11. Nakae R, Murai Y, Yokobori S (2022) Biomarkers in neurological injury: fibrinogen, fibrinogen/fibrin degradation products (FDPs), and D-dimer. In: Biomarkers in trauma, injury and critical care. Springer, pp 1–15

  12. Kasperska-Zajac A, Brzoza Z (2009) Increased D-dimer concentration in plasma of patients with severe acute urticaria. Br J Dermatol 161:1409–1410

    Article  CAS  PubMed  Google Scholar 

  13. Takahagi S, Mihara S, Iwamoto K, Morioke S, Okabe T, Kameyoshi Y et al (2010) Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria. Allergy 65:649–656

    Article  CAS  PubMed  Google Scholar 

  14. Schaefer P (2017) Acute and chronic urticaria: evaluation and treatment. Am Fam Physician 95:717–724

    PubMed  Google Scholar 

Download references

Funding

National Natural Science Foundation of China (82102416, 82202635), Young Science and Technology Project (2022KJXX-26). Shaanxi Provincial People’s Hospital 2021 Jingying Project (2021JY-01).

Author information

Author notes

  1. Lei Zhang and Weiwei Jiang contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, People’s Republic of China

    Lei Zhang

  2. Department of Dermatology, 72nd Group Army Hospital of PLA, Huzhou, Zhejiang, People’s Republic of China

    Weiwei Jiang

  3. Department of Laboratory Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China

    Yacob Berhane Gebreab & Xin Ye

Authors
  1. Lei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Weiwei Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yacob Berhane Gebreab
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xin Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

LZ and XY wrote the main manuscript text and designed this study. WJ and YBG performed the data collection. WJ prepared figure1 and table 1.  YBG prepared figures 2-3 and table 2. All authors reviewed the manuscript.

Corresponding author

Correspondence to Xin Ye.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, L., Jiang, W., Gebreab, Y.B. et al. Increased d-dimer and fibrin degradation product levels as potential indicators for evaluating infection-related acute urticaria: a case-case–control study. Arch Dermatol Res 315, 2871–2876 (2023). https://doi.org/10.1007/s00403-023-02706-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-023-02706-2

Keywords

Search

Navigation