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The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive

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Abstract

Hematopoietic stem cell transplantation is increasing in frequency with graft-versus-host disease affecting many recipients. When the skin is involved, biopsy is routinely performed but often does not aid in definitive diagnosis. Here, we examine a cohort of 32 patients for potential biomarkers that can aid in the diagnosis of graft-versus-host disease. Neither blood short tandem repeat testing or neutrophil–lymphocyte ratios were predictive of rash etiology in hematopoietic stem cell transplant patients. However, skin short tandem repeat testing showed promise as a predictor in a small minority of cases in this cohort.

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Data is available by request.

References

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Funding

None to declare.

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Authors and Affiliations

  1. Department of Dermatology, Henry Ford Health, Detroit, MI, USA

    Aaron Tisack, Sasank Konda & Jesse Veenstra

Authors
  1. Aaron Tisack
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  2. Sasank Konda
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  3. Jesse Veenstra
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Contributions

AT: data acquisition and analysis, writing of manuscript. SK: study conceptualization and design, editing of manuscript. JV: study conceptualization and design, data analysis, editing of manuscript.

Corresponding author

Correspondence to Jesse Veenstra.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approved was granted by the Henry Ford Health Institutional Review Board (15548).

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Tisack, A., Konda, S. & Veenstra, J. The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive. Arch Dermatol Res 315, 2467–2469 (2023). https://doi.org/10.1007/s00403-023-02671-w

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  • DOI: https://doi.org/10.1007/s00403-023-02671-w

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