Abstract
Tremella fuciformis, also known as snow mushroom, is an edible mushroom that has historically been popular in herbal and Asian medicine and cuisine. The main polysaccharide ingredients have been extracted and used as treatment in a variety of conditions, demonstrating positive effects in a range of biological functions including those involved in antioxidation, antitumor, antidiabetic, immunomodulatory, and neuroprotective pathways. Studies have demonstrated the role this extract may play in skin antiaging, photoprotection, wound healing, and barrier protection. Most studies have been limited to in vitro and in vivo animal models. Future clinical research is needed to further understand the role of T. fuciformis in dermatology. This review will discuss the existing research findings and potential future applications for T. fuciformis as a treatment in skin conditions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
The data that support the evidence presented in this article is accessible from public databases including PubMed.
References
Shen T, Duan C, Chen B et al (2017) Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1. Mol Med Rep 16(2):1340–1346
Chiang JH, Tsai FJ, Lin TH, Yang JS, Chiu YJ (2022) Tremella fuciformis inhibits melanogenesis in B16F10 cells and promotes migration of human fibroblasts and keratinocytes. In Vivo 36(2):713–722
Lourith N, Pungprom S, Kanlayavattanakul M (2021) Formulation and efficacy evaluation of the safe and efficient moisturizing snow mushroom hand sanitizer. J Cosmet Dermatol 20(2):554–560
Fu H, You S, Zhao D et al (2021) Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways. J Cosmet Dermatol 20(12):4052–4059
Xie L, Yang K, Liang Y, Zhu Z, Yuan Z, Du Z (2022) Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota. Front Pharmacol 13:944801
Yang D, Liu Y, Zhang L (2019) Tremella polysaccharide: the molecular mechanisms of its drug action. Prog Mol Biol Transl Sci 163:383–421
Wu DT, An LY, Liu W, Hu YC, Wang SP, Zou L (2022) In vitro fecal fermentation properties of polysaccharides from Tremella fuciformis and related modulation effects on gut microbiota. Food Res Int 156:111185
Xu Y, Xie L, Zhang Z et al (2021) Tremella fuciformis polysaccharides inhibited colonic inflammation in dextran sulfate sodium-treated mice via Foxp3+ T cells, gut microbiota, and bacterial metabolites. Front Immunol 12:648162
Wu YJ, Wei ZX, Zhang FM, Linhardt RJ, Sun PL, Zhang AQ (2019) Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: a review. Int J Biol Macromol 121:1005–1010
The global skincare market is projected to grow from $100.13 billion in 2021 to $145.82 billion in 2028 at a CAGR of 5.52% in forecast period, 2021–2028. Fortune Business Insights 2021. https://www.fortunebusinessinsights.com/skin-care-market-102544. Accessed 10 Nov 2022
Huang A, Nguyen JK, Ho D, Jagdeo J (2020) Light emitting diode phototherapy for skin aging. J Drugs Dermatol 19(4):359–364
Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K (2015) Oxidative stress in aging human skin. Biomolecules 5(2):545–589
Taylor SC, Alexis AF, Armstrong AW, Chiesa Fuxench ZC, Lim HW (2022) Misconceptions of photoprotection in skin of color. J Am Acad Dermatol 86(3s):S9-s17
Serravallo M, Jagdeo J, Glick SA, Siegel DM, Brody NI (2013) Sirtuins in dermatology: applications for future research and therapeutics. Arch Dermatol Res 305(4):269–282
Wen L, Gao Q, Ma CW et al (2016) Effect of polysaccharides from Tremella fuciformis on UV-induced photoaging. J Funct Foods 20:400–410. https://doi.org/10.1016/j.jff.2015.11.014
Mandlik DS, Mandlik SK (2021) Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies. Immunopharmacol Immunotoxicol 43(2):105–125
Avena-Woods C (2017) Overview of atopic dermatitis. Am J Manag Care 23(8 Suppl):S115-s123
Fan XZ, Yao F, Yin CM, Shi DF, Gao H (2020) Optimization of fermentation process and its impact on gene transcription of intracellular polysaccharide synthesis in the wood ear medicinal mushroom auricularia auricula-judae (Agaricomycetes). Int J Med Mushrooms 22(6):581–592
Liang CH, Wu CY, Lu PL, Kuo YC, Liang ZC (2019) Biological efficiency and nutritional value of the culinary-medicinal mushroom Auricularia cultivated on a sawdust basal substrate supplement with different proportions of grass plants. Saudi J Biol Sci 26(2):263–269
Funding
None.
Author information
Authors and Affiliations
Contributions
JM performed the literature search and wrote the main manuscript. JJ helped to develop the concept and edit/review the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Mineroff, J., Jagdeo, J. The potential cutaneous benefits of Tremella fuciformis. Arch Dermatol Res 315, 1883–1886 (2023). https://doi.org/10.1007/s00403-023-02550-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00403-023-02550-4