Abstract
Psoriasis and sarcoidosis are inflammatory skin and systemic diseases that may share a similar immunopathogenesis involving a Th1 and/or Th17 polarized immune response. Although the coexistence of sarcoidosis and psoriasis in the same individuals has been reported, the potential association between these diseases at a population-level in the United States has not been evaluated. To evaluate this association, we performed a matched cross-sectional study in the All of Us research program database. In the multivariable analysis of 4932 psoriasis cases and 19,728 controls, sarcoidosis was found to be significantly associated with psoriasis (OR 2.37 [95% CI 1.73–3.23], p < 0.001). The relative strength of this association between psoriasis and sarcoidosis may be, in part, explained by overlapping immunopathogenesis and common genetic susceptibility of these diseases. Taken together, these observations underscore the need for screening psoriasis patients for development of new cardiopulmonary symptoms. Further research into the mechanism of this relationship and its implications is warranted.
This is a preview of subscription content, log in via an institution to check access.
Data availability statement
The All of Us research dataset is available for access at www.allofus.nih.gov. The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.
References
Balding J, Kane D, Livingstone W et al (2003) Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. Arthritis Rheum 48(5):1408–1413. https://doi.org/10.1002/art.10935
Baughman RP, Field S, Costabel U et al (2016) Sarcoidosis in America. Analysis based on health care use. Ann Am Thorac Soc 13(8):1244–1252. https://doi.org/10.1513/AnnalsATS.201511-760OC
Khalid U, Gislason GH, Hansen PR (2014) Sarcoidosis in patients with psoriasis: a population-based cohort study. PLoS ONE 9(10):e109632. https://doi.org/10.1371/journal.pone.0109632
Medica I, Kastrin A, Maver A, Peterlin B (2007) Role of genetic polymorphisms in ACE and TNF-alpha gene in sarcoidosis: a meta-analysis. J Hum Genet 52(10):836–847. https://doi.org/10.1007/s10038-007-0185-7
Murphy MJ, Cohen JM, Vesely MD, Damsky W (2020) Paradoxical eruptions to targeted therapies in dermatology: a systematic review and analysis. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2020.12.010
Nedoszytko B, Szczerkowska-Dobosz A, Zabłotna M, Gleń J, Rebała K, Roszkiewicz J (2007) Associations of promoter region polymorphisms in the tumour necrosis factor-alpha gene and early-onset psoriasis vulgaris in a northern Polish population. Br J Dermatol 157(1):165–167. https://doi.org/10.1111/j.1365-2133.2007.07993.x
Wallace EB, Khosravi H, Joyce CJ, Vleugels FR, Patel M (2018) Examining the epidemiology of coincident psoriasis and sarcoidosis: an observational cross-sectional study. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2018.11.009
Wanat KA, Schaffer A, Richardson V, VanVoorhees A, Rosenbach M (2013) Sarcoidosis and psoriasis: a case series and review of the literature exploring co-incidence vs coincidence. JAMA Dermatol 149(7):848–852. https://doi.org/10.1001/jamadermatol.2013.4256
Funding
There is no funding source.
Author information
Authors and Affiliations
Contributions
Conceptualization: WD, JMC; Data curation: MJM; Formal analysis: MJM; Investigation: MJM; Methodology: MJM, WD, JMC; Project administration: MJM, WD, JMC; Software: MJM, ACL; Supervision: WD, JMC; Validation: MJM; Visualization: MJM; Writing - original draft: MJM; Writing - review & editing: JMC, WD, ACL
Corresponding author
Ethics declarations
Conflict of interest
WD is a consultant for Pfizer, Incyte, Eli Lilly, and TWi Biotechnology, has research funding from Pfizer, Advanced Cell Diagnostics/Bio-techne, and AbbVie and receives licensing fees from EMD/Millipore/Sigma. JMC serves on a data and safety monitoring board for Advarra. MJM and ACL have no conflicts to disclose.
IRB approval status
This study (2000030542) has been deemed not to be human subjects research by the Yale University Institutional Review Board.
Clinicaltrials.gov (or equivalent) listing (if applicable)
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Murphy, M.J., Leasure, A.C., Damsky, W. et al. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Arch Dermatol Res 315, 1439–1441 (2023). https://doi.org/10.1007/s00403-022-02488-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00403-022-02488-z