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Psoriasis in the transplant population

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Abstract

Solid organ and stem cell transplants are increasingly common, and dermatologists will more frequently encounter and need to manage common skin diseases, such as psoriasis, in transplant patients. This review explores psoriasis remission and occurrence in recipients of solid organ and stem cell transplants. Hematopoietic and mesenchymal stem cell transplants may show potential for treating psoriasis in patients with leukemia or who have other medical conditions requiring stem cell transplant. The effects of solid organ transplant are less clear, partly due to limitations in the breadth of the literature. De novo psoriasis has been reported in recipients of solid organ transplants, but the reasons for this development have yet to be fully understood. Overall, the literature on this subject is limited to primarily case reports. Feasibility of studies on the subject may be a considerable barrier to further research assessing the use of transplant for treating psoriasis, but there is potential benefit from transplant for psoriasis patients. This subject should receive further exploration to fully understand these benefits.

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Abbreviations

AML:

Acute myeloid leukemia

BMT:

Bone marrow transplant

BSA:

Body surface area

CBT:

Cord blood transplant

CML:

Chronic myeloid leukemia

DLBCL:

Diffuse large B cell lymphoma

GVHD:

Graft-versus-host disease

HSCT:

Hematopoietic stem cell transplant

MGUS:

Monoclonal gammopathy of undetermined significance

MSC:

Mesenchymal stem cells

NBUVB:

Narrowband ultraviolet B

NIS:

Nationwide Inpatient Sample

PASI:

Psoriasis Area and Severity Index

PBSCT:

Peripheral blood stem cell transplant

RIST:

Reduced-intensity stem cell transplantation

Txp:

Transplant

UCMSC:

Umbilical cord-derived mesenchymal stem cells

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Authors and Affiliations

  1. School of Medicine, University of Utah, Salt Lake City, UT, USA

    Nathanael C. Jensen

  2. Department of Dermatology, University of Utah, 30 North 1900 East, 4A330, Salt Lake City, UT, 84132, USA

    Jacob Robins, Ashley M. Snyder & Luke Johnson

  3. Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA

    Ashley M. Snyder

  4. Meridian Dermatology, Meridian, ID, USA

    Ryan Harris

  5. Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA

    Laura Korb Ferris

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Contributions

LJ and LKF developed initial ideas for this manuscript, and LJ, NCJ, JR, and AS were the primary authors of manuscript content. RH and LKF contributed to the initial drafts of this manuscript. RH provided additional content revisions for the final draft. All authors provided input on article content and had a chance to review the manuscript before submission.

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Correspondence to Luke Johnson.

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Conflict of interest

Ryan Harris has served as an investigator for Bristol Meyers Squib and Eli Lilly. Laura Korb Ferris has received compensation for participation as an investigator in clinical trials from Amgen, Abbvie, UCB, Eli Lilly, Novartis, Janssen, Nimbus, Dermavant, and Arcutis. Dr. Ferris has received consulting honoraria from Eli Lilly, Abbvie, Arcutis, Dermavant, Janssen, Bristol-Myers Squibb, Ortho Bausch, and Sun Pharma. Dr. Ferris has received honoraria for participating in data safety monitoring boards from Bristol-Myers Squibb and Pfizer. Luke Johnson co-hosts the not-for-profit podcasts Dermasphere and Skincast. All other authors have no conflicts to declare.

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Jensen, N.C., Robins, J., Snyder, A.M. et al. Psoriasis in the transplant population. Arch Dermatol Res 315, 1109–1128 (2023). https://doi.org/10.1007/s00403-022-02487-0

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