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Hidradenitis suppurativa and sleep: a systematic review

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Abstract

Chronic inflammatory skin disorders are known to affect sleep quality; however, the relationship between hidradenitis suppurativa (HS) and sleep is not well understood. We performed a systematic review of HS and sleep disorders and sleep quality in HS patients. We identified seven studies comprising 343,870 subjects. We found that HS patients have a higher likelihood of having a sleep disorder such as obstructive sleep apnea, as well as other non-sleep apnea. Several studies showed that patients reported worse sleep quality due to symptoms of HS such as pruritus and pain. HS patients may be at risk for additional cardiovascular comorbidities and poorer quality of life secondary to these sleep disorders and poor sleep quality. Further high-quality research evaluating these associations is warranted.

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Authors and Affiliations

  1. Department of Dermatology, University of California, 515 Spruce Street, San Francisco, CA, 94118, USA

    Samuel Yeroushalmi, Alexander Ildardashty, Kareem G. Elhage, Mimi Chung, Erin Bartholomew, Marwa Hakimi, Haley B. Naik, Tina Bhutani & Wilson Liao

  2. University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA

    Peggy Tahir

Authors
  1. Samuel Yeroushalmi
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  2. Alexander Ildardashty
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  3. Kareem G. Elhage
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  4. Mimi Chung
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  5. Erin Bartholomew
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  6. Marwa Hakimi
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  7. Peggy Tahir
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  8. Haley B. Naik
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  9. Tina Bhutani
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  10. Wilson Liao
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Contributions

SY, AI, and KE conceptualized, wrote, and edited the main manuscript text. SY and AI created figure 1 and table 1. MC, EB, and MH edited the main manuscript. PT conducted the review. HN, TB, and WL conceptualized and edited the manuscript.

Corresponding author

Correspondence to Samuel Yeroushalmi.

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Conflict of interest

Haley Naik has received grant support from Abbvie; consulting fees from 23andme, Abbvie, Aristea Therapeutics, Nimbus Therapeutics, Medscape, and DAVA Oncology; advisory board fees from Boehringer Ingelheim; and investigator fees from Pfizer. She is also an Associate Editor for JAMA Dermatology and an unpaid board member of the US Hidradenitis Suppurativa Foundation. Tina Bhutani is a principal investigator for trials sponsored by Abbvie, Castle, CorEvitas, Dermavant, Galderma, Mindera, and Pfizer. She has received research grant funding from Novartis and Regeneron. She has been an advisor for Abbvie, Arcutis, Boehringer Ingelheim, Bristol Myers Squibb, Janssen, Leo, Lilly, Novartis, Pfizer, Sun, and UCB. Wilson Liao has received research grant funding from Abbvie, Amgen, Janssen, Leo, Novartis, Pfizer, Regeneron, and TRex Bio. The remaining authors have nothing to disclose.

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Yeroushalmi, S., Ildardashty, A., Elhage, K.G. et al. Hidradenitis suppurativa and sleep: a systematic review. Arch Dermatol Res 315, 1409–1415 (2023). https://doi.org/10.1007/s00403-022-02460-x

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  • DOI: https://doi.org/10.1007/s00403-022-02460-x

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