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Comparative study between topical steroid alone versus combined fractional Erbium:YAG laser with topical steroid in treatment of alopecia areata

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Abstract

AA is a common autoimmune skin disease that causes hair loss on the scalp and sometimes other areas of the body. New therapy approaches for alopecia areata are emerging, with the goal of improving clinical outcomes. In this study, the effects of topical steroids against fractional Er:YAG laser followed by topical steroids in the treatment of alopecia areata will be compared. A total of 30 participants with alopecia areata were included in the study. Each patient's lesions were treated with one of two methods: topical clobetasol propionate or fractional Er:YAG laser followed by topical clobetasol propionate. SALT score, patient satisfaction, and dermoscopic imaging were used to evaluate therapeutic response. Both treatment modalities showed a significant clinical improvement in alopecia areata with a statistically significant reduction in the SALT score. The SALT score was more evident in the laser-steroid group. On comparing the dermoscopy findings in both treated areas before and after treatment, a significant reduction was found regarding all dermoscopic findings of alopecia areata in both modalities. Combining fractional Er:YAG laser with topical steroids is found to be a safe treatment modality and more effective than topical steroids in alopecia areata.

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This is a contributors' own work, and the working team didn't receive any funds.

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Authors and Affiliations

  1. Dermatology, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt

    Hesham Ali Shokeir

  2. Dermatology Department, Al-Houd El-Marsoud Hospital, Cairo, Egypt

    Anas Yousry

  3. Dermatology, Faculty of Medicine-Al-Azhar University, Cairo, Egypt

    Shady Mahmoud Attia Ibrahim

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  1. Hesham Ali Shokeir
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  2. Anas Yousry
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  3. Shady Mahmoud Attia Ibrahim
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Correspondence to Shady Mahmoud Attia Ibrahim.

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Shokeir, H.A., Yousry, A. & Ibrahim, S.M.A. Comparative study between topical steroid alone versus combined fractional Erbium:YAG laser with topical steroid in treatment of alopecia areata. Arch Dermatol Res 315, 241–247 (2023). https://doi.org/10.1007/s00403-022-02417-0

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  • DOI: https://doi.org/10.1007/s00403-022-02417-0

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