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Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001–2016

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Abstract

Background

Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD).

Objective

To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diagnosis.

Methods

Retrospective analysis from 2001 to 2016 of 38,723 patients from the North American Contact Dermatitis Group.

Results

After patch testing, 303 (0.7%) patients were diagnosed with SD; 46.7% had a concomitant diagnosis of ACD. Patients with vs. without a final SD diagnosis had similar proportions of ≥ 1 positive allergic reaction (59.7% vs. 64.7%; Chi-square, P = 0.0724) but higher odds of allergic reactions to fragrance mix I, bacitracin, quaternium-15, Myroxylon pereirae, benzalkonium chloride, ethyleneurea melamine formaldehyde, diazolidinyl urea, and propylene glycol. The most commonly relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde. The most common allergen sources were personal care products, topical medications and other health aid products.

Conclusion

Nearly half of patients with a final SD diagnosis were also diagnosed with ACD, supporting the role of patch testing in select SD patients.

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Author information

Author notes

  1. Jonathan I. Silverberg and Alexander Hou contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Dermatology, School of Medicine, George Washington University, 2150 Pennsylvania Avenue, Suite 2B-425, Washington, DC, 20037, USA

    Jonathan I. Silverberg

  2. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Evanston, USA

    Alexander Hou

  3. Department of Dermatology, Park Nicollet Health Services, Minneapolis, MN, USA

    Erin M. Warshaw

  4. Department of Dermatology, University of Minnesota, Minneapolis, MN, USA

    Erin M. Warshaw

  5. Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, USA

    Erin M. Warshaw

  6. Department of Dermatology, University of California San Francisco, San Francisco, USA

    Howard I. Maibach

  7. Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA

    Donald V. Belsito

  8. Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

    Joel G. DeKoven

  9. Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Kathryn A. Zug

  10. Department of Dermatology, Cleveland Clinic, Cleveland, OH, USA

    James S. Taylor

  11. Division of Dermatology, Montreal General Hospital, McGill University, Montreal, QC, Canada

    Denis Sasseville

  12. Associates in Dermatology, Fort Myers, FL, USA

    Anthony F. Fransway

  13. Department of Dermatology, Keck School of Medicine, Los Angeles, CA, USA

    Vincent A. DeLeo

  14. Division of Dermatology, University of Ottawa, Ottawa, ON, Canada

    Melanie D. Pratt

  15. Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA

    Margo J. Reeder

  16. Department of Dermatology, Duke University Medical Center, Durham, NC, USA

    Amber R. Atwater

  17. Division of Dermatology, University of Louisville, Louisville, KY, USA

    Joseph F. Fowler Jr

  18. Department of Dermatology, Ohio State University, Columbus, USA

    Matthew J. Zirwas

  19. Department of Dermatology, Pennsylvania State University, State College, USA

    James G. Marks Jr

Authors
  1. Jonathan I. Silverberg
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  2. Alexander Hou
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  3. Erin M. Warshaw
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  4. Howard I. Maibach
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  7. Kathryn A. Zug
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  9. Denis Sasseville
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  15. Joseph F. Fowler Jr
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Corresponding author

Correspondence to Jonathan I. Silverberg.

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Conflicts of interest

Denis Sasseville receives royalties from UpToDate (Wolters Kluwer Health). JST owns non-controlling common stock in Cigna, Merck, Johnson and Johnson, Astra Zeneca and Opko Health; is a member of the Cosmetic Ingredient Review Steering Committee; and a non-dependent child is employed by Pfizer. EW has served as a consultant for Wen by Chaz Dean and Noven Pharmaceuticals as well as a grant funded by Wen by Chaz Dean. ARA received a Pfizer Independent Grant for Learning & Change and has consulted for Henkel.

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Silverberg, J.I., Hou, A., Warshaw, E.M. et al. Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001–2016. Arch Dermatol Res 314, 857–867 (2022). https://doi.org/10.1007/s00403-021-02295-y

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  • DOI: https://doi.org/10.1007/s00403-021-02295-y

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