Abstract
Although the majority of lymphomas are diagnosed in lymph nodes, bone marrow, or other viscera, initial diagnosis of systemic lymphomas in the skin is a rare but important occurrence in dermatology. This study seeks to quantify the incidence of initial skin presentation in patients with systemic B-cell lymphomas (BCL) via examination of data in the Surveillance, Epidemiology, and End Results (SEER)-18 database; cases of primary cutaneous B-cell lymphoma were excluded. We found that an initial diagnosis of lymphoma in the skin is a very rare occurrence for systemic B-cell lymphomas, comprising < 0.3% of cases overall. Follicular lymphoma was the most likely to be diagnosed in the skin (1.47%), followed by marginal zone lymphoma (MZL, 0.5%), mantle cell lymphoma (0.4%), diffuse large B-cell lymphoma (DLBCL, 0.23%), Burkitt lymphoma (0.23%), Hodgkin lymphoma (0.04%), and chronic lymphocytic leukemia (0.006%). While indolent systemic lymphomas (MZL and FL) presenting initially in the skin have a better prognosis than those presenting at other sites, the more aggressive systemic DLBCL presenting in the skin does not demonstrate improved prognosis.
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Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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AG had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: AG. Acquisition, analysis, and interpretation of data: AG. Drafting of the manuscript: NG. Critical revision of the manuscript for important intellectual content: AG, NG. Statistical analysis: NR, AG. Obtained funding: NR. Administrative, technical, or material support: AG. Study supervision and research mentorship: AG.
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Goyal, N., Rubin, N. & Goyal, A. Differential survival of systemic B-cell lymphomas initially diagnosed in the skin: a population-based study of 883 patients. Arch Dermatol Res 315, 259–263 (2023). https://doi.org/10.1007/s00403-021-02293-0
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DOI: https://doi.org/10.1007/s00403-021-02293-0