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Intense Pulsed Light on skin rejuvenation: a systematic review

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Aged skin is characterized by appearance of wrinkles, vascular lesions, hyperpigmentation, lentignes, texture, rhytides, and pores. These changes occur under the influence of intrinsic and extrinsic factors, as hormone alterations and exposure to ultraviolet light (UV) irradiation, respectively. Skin changes associated with aging have been assuming an important role in nowadays and bring to affect the quality of life. Intense Pulsed Light (ILP) is a noncollimated, polychromatic, and noncoherent non-surgical cosmetic therapy to skin rejuvenation. This is the first systematic review evaluating ILP treatment on skin rejuvenation evaluated by digital photographs and self-reported treatment efficacy. A PRISMA compliant review includes a search of the databases Scopus and PubMed. Sixteen studies treating 637 participants (with Fitzpatrick skin types I to IV and age varying from 21 to 80 years) were included. Patients were treated a mean of 4.29 sessions (range 3–7). The most studies results showed the efficacy of IPL treatment in telangiectasia, wrinkles, pore, erythema, rhytids, texture, lentigines, hiperpigmentation, and photoaging score. Six studies showed IPL-positive effects in association with other treatment and seven studies showed superior effect of other treatment or association to IPL with other treatment related to IPL alone. Nine studies showed low methodological quality. In conclusion, ILP treatment is effective on skin rejuvenation. However, there is no consensus about the parameters and future studies are needed to sample size limitations, made RCTs with low risk of bias, and improve the methodological quality its. Trial registration: Prospero Systematic Review Registration ID: CRD42021237817.

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  1. Augustyniak A, Rotsztejn H (2017) Intense pulsed light (IPL) treatment for the skin in the eye area–clinical and cutometric analysis. J Cosmet Laser Ther 19:18–24.

    Article  PubMed  Google Scholar 

  2. Babilas P, Schreml S, Landthaler M et al (2010) Photodynamic therapy in dermatology: state-of-the-art. Photodermatol Photoimmunol Photomed 26:118–132

    Article  CAS  Google Scholar 

  3. Babilas P, Schreml S, Szeimies RM et al (2010) Intense pulsed light (IPL): a review. Lasers Surg Med 42:93–104.

    Article  PubMed  Google Scholar 

  4. Barikbin B, Akbari Z, Vafaee R et al (2019) The efficacy of IPL in periorbital skin rejuvenation: An open-label study. J Lasers Med Sci 10:S64–S67.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Baumann L (2018) How to use oral and topical cosmeceuticals to prevent and treat skin aging. Facial Plast Surg Clin North Am.

    Article  PubMed  Google Scholar 

  6. Boismal F, Serror K, Dobos G, Zuelgaray E, Bensussan A, Michel L (2020) Vieillissement cutané - Physiopathologie et thérapies innovantes [skin aging:pathophysiology and innovative therapies]. Med Sci (Paris) 36(12):1163–1172.

    Article  Google Scholar 

  7. Carruthers J, Fagien S, Matarasso SL (2004) Consensus recommendations on the use of botulinum toxin type A in facial aesthetics. Plast Reconstr Surg 114:1–22.

    Article  Google Scholar 

  8. Chen Y, Li J, Wu Y, Lin X, Deng X, Yun-e Z (2021) Comparative evaluation in intense pulsed light therapy combined with or without meibomian gland expression for the treatment of meibomian gland dysfunction. Curr Eye Res.

    Article  PubMed  PubMed Central  Google Scholar 

  9. DiBernardo BE, Pozner JN (2016) Intense pulsed light therapy for skin rejuvenation. Clin Plast Surg.

    Article  PubMed  Google Scholar 

  10. Dinsdale G, Murray A, Moore T, Ferguson J, Wilkinson J, Richards H, Griffiths CE, Herrick AL (2014) A comparison of intense pulsed light and laser treatment of telangiectases in patients with systemic sclerosis: a within-subject randomized trial. Rheumatol (Oxford) 53(8):1422–1430.

    Article  Google Scholar 

  11. Feng Y, Zhao J, Gold MH (2008) Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanismsof intense pulsed light. J Drugs Dermatol 7(3):273–279

    PubMed  Google Scholar 

  12. Farage MA, Miller KW, Elsner P, Maibach HI (2013) Characteristics of the aging skin. Adv Wound Care (New Rochelle) 2(1):5–10.

    Article  Google Scholar 

  13. Fodor L, Carmi N, Fodor A, Ramon Y, Ullmann Y (2009) Intense pulsed light for skin rejuvenation, hair removal, and vascular lesions: a patient satisfaction study and review of the literature. Ann Plast Surg 62(4):345–349.

    Article  CAS  PubMed  Google Scholar 

  14. Freedman BM (2009) Topical polyphenolic antioxidants reduce the adverse effects of intense pulsed light therapy. J Cosmet Laser Ther 11(3):142–145.

    Article  PubMed  Google Scholar 

  15. Galeckas KJ, Collins M, Ross EV, Uebelhoer NS (2008) Split-face treatment of facial dyschromia: pulsed dye laser with a compression handpiece versus intense pulsed light. Dermatol Surg 34(5):672–680.

    Article  CAS  PubMed  Google Scholar 

  16. Gold MH, Biron JA, Sensing W (2016) Facial skin rejuvenation by combination treatment of IPL followed by continuous and fractional radiofrequency. J Cosmet Laser Ther 18:2–6.

    Article  PubMed  Google Scholar 

  17. Goldberg DJ (2012) Current trends in intense pulsed light. J Clin Aesthet Dermatol 5(6):45–53

    PubMed  PubMed Central  Google Scholar 

  18. Goldberg DJ, Cutler KB (2000) Nonablative treatment of rhytids with intense pulsed light. Lasers Surg Med 26:196–200.;2-9

    Article  CAS  PubMed  Google Scholar 

  19. González-Rodríguez AJ, Lorente-Gual R (2015) Indicaciones actuales y nuevas aplicaciones de los sistemas de luz pulsada intensa. Actas Dermosifiliogr 106:350–364

    Article  Google Scholar 

  20. Gutop EO, Diatlova AS, Linkova NS, Orlova OA, Trofimova SV, Khavinson VK (2019) Aging of skin fibroblasts: genetic and epigenetic factors. Adv Gerontol 32(6):908–914

    CAS  PubMed  Google Scholar 

  21. Hedelund L, Bjerring P, Egekvist H, Haedersdal M (2006) Ablative versus non-ablative treatment of perioral rhytides. A randomized controlled trial with long-term blinded clinical evaluations and non-invasive measurements. Lasers Surg Med 38(2):129–136.

    Article  CAS  PubMed  Google Scholar 

  22. Hedelund L, Due E, Bjerring P, Wulf HC, Haedersdal M (2006) Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation. Arch Dermatol 142(8):985–990.

    Article  PubMed  Google Scholar 

  23. Iyer S, Carranza D, Kolodney M, Macgregor D, Chipps L, Soriano T (2007) Evaluation of procollagen I deposition after intense pulsed light treatments at varying parameters in a porcine model. J Cosmet Laser Ther 9(2):75–78.

    Article  PubMed  Google Scholar 

  24. Jørgensen GF, Hedelund L, Hædersdal M (2008) Long-pulsed dye laser versus intense pulsed light for photodamaged skin: a randomized split-face trial with blinded response evaluation. Lasers Surg Med 40(5):293–299.

    Article  PubMed  Google Scholar 

  25. Kligman DE, Zhen Y (2004) Intense pulsed light treatment of photoaged facial skin. Dermatol Surg 30(8):1085–1090.

    Article  PubMed  Google Scholar 

  26. Knight JM, Kautz G (2019) Sequential facial skin rejuvenation with intense pulsed light and non ablative fractionated laser resurfacing in fitzpatrick skin type II–IV patients: a prospective multicenter analysis. Lasers Surg Med 51(2):141–149.

    Article  PubMed  Google Scholar 

  27. Li YH, Wu Y, Chen JZ, Zhu X, Xu YY, Chen J, Dong GH, Gao XH, Chen HD (2010) A split-face study of intense pulsed light on photoaging skin in Chinese population. Lasers Surg Med 42(2):185–191.

    Article  PubMed  Google Scholar 

  28. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6(7):e1000100.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Maruyama S (2016) Hand rejuvenation using standard Intense Pulsed Light (IPL) in Asian patients. Laser Ther 25(1):43–54.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Mezzana P (2008) ‘Multi Light and Drugs’: a new technique to treat face photoaging: comparative study with photorejuvenation. Lasers Med Sci 23(2):149–154.

    Article  PubMed  Google Scholar 

  31. Moravvej H, Saeedi M (2011) Intense pulsed light and red light photo rejuvenation for skin rejuvenation: a split face clinical trial. J Lasers Med Sci 29(2):63–66

    Google Scholar 

  32. Negishi K, Kushikata N, Takeuchi K, Tezuka Y, Wakamatsu S (2006) Photorejuvenation by intense pulsed light with objective measurement of skin color in Japanese patients. Dermatol Surg 32:1380–1387.

    Article  CAS  PubMed  Google Scholar 

  33. Newton VL, Mcconnell JC, Hibbert SA, Graham HK, Watson RE (2015) Skin aging: molecular pathology, dermal remodelling and the imaging revolution. G Ital Dermatol Venereol 150(6):665–674

    CAS  PubMed  Google Scholar 

  34. Santos RV, Titus RG, Lima HC (2007) Objective evaluation of skin prick test reactions using digital photography. Skin Res Technol 13(2):148–153.

    Article  PubMed  Google Scholar 

  35. Sturgill WH, Leach BC, Spolyar MM, Ross EV (2005) Evaluation of a novel Flash Lamp System (FLS) incorporating optimal spectral filtration for the treatment of photoaging. Lasers Surg Med 37(2):108–113.

    Article  PubMed  Google Scholar 

  36. Tao L, Wu J, Qian H, Lu Z, Li Y, Wang W, Zhao X, Tu P, Yin R, Xiang L (2015) Intense pulsed light, near infrared pulsed light, and fractional laser combination therapy for skin rejuvenation in Asian subjects: a prospective multi-center study in China. Lasers Med Sci 30(7):1977–1983.

    Article  PubMed  Google Scholar 

  37. Town G, Ash C, Eadie E, Moseley H (2007) Measuring key parameters of intense pulsed light (IPL) devices. J Cosmet Laser Ther 9(3):148–160.

    Article  PubMed  Google Scholar 

  38. Verner I, Kutscher TD (2017) Clinical evaluation of the efficacy and safety of combined bipolar radiofrequency and optical energies vs. optical energy alone for the treatment of aging hands. Lasers Med Sci 32(6):1387–1392.

    Article  PubMed  Google Scholar 

  39. Xi Z, Shuxian Y, Zhong L, Hui Q, Yan W, Huilin D, Leihong X, Gold MH (2011) Topical 5-aminolevulinic acid with intense pulsed light versus intense pulsed light for photodamage in Chinese patients. Dermatol Surg 37(1):31–40.

    Article  CAS  PubMed  Google Scholar 

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Not applicable. This research was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (Grant 2020/01513-5).

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The project was conceptualized and designed by ACMR. CSSM submitted the project in PROSPERO. AFS, ILP, and MAC analyzed independently the title and the abstract of the studies and selected the potential works according to the inclusion and the exclusion criteria. Tables and figures were made by AFS, ILP, PGV, and JPR. ACMR, AFSS, PGV, and ILP drafted the article, and LAG and CCSM critically revised the article.

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Correspondence to Patricia Gabrielli Vassão.

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Sales, A.F.S., Pandolfo, I.L., de Almeida Cruz, M. et al. Intense Pulsed Light on skin rejuvenation: a systematic review. Arch Dermatol Res 314, 823–838 (2022).

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