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Intense Pulsed Light on skin rejuvenation: a systematic review

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Abstract

Aged skin is characterized by appearance of wrinkles, vascular lesions, hyperpigmentation, lentignes, texture, rhytides, and pores. These changes occur under the influence of intrinsic and extrinsic factors, as hormone alterations and exposure to ultraviolet light (UV) irradiation, respectively. Skin changes associated with aging have been assuming an important role in nowadays and bring to affect the quality of life. Intense Pulsed Light (ILP) is a noncollimated, polychromatic, and noncoherent non-surgical cosmetic therapy to skin rejuvenation. This is the first systematic review evaluating ILP treatment on skin rejuvenation evaluated by digital photographs and self-reported treatment efficacy. A PRISMA compliant review includes a search of the databases Scopus and PubMed. Sixteen studies treating 637 participants (with Fitzpatrick skin types I to IV and age varying from 21 to 80 years) were included. Patients were treated a mean of 4.29 sessions (range 3–7). The most studies results showed the efficacy of IPL treatment in telangiectasia, wrinkles, pore, erythema, rhytids, texture, lentigines, hiperpigmentation, and photoaging score. Six studies showed IPL-positive effects in association with other treatment and seven studies showed superior effect of other treatment or association to IPL with other treatment related to IPL alone. Nine studies showed low methodological quality. In conclusion, ILP treatment is effective on skin rejuvenation. However, there is no consensus about the parameters and future studies are needed to sample size limitations, made RCTs with low risk of bias, and improve the methodological quality its. Trial registration: Prospero Systematic Review Registration ID: CRD42021237817.

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Funding

Not applicable. This research was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (Grant 2020/01513-5).

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The project was conceptualized and designed by ACMR. CSSM submitted the project in PROSPERO. AFS, ILP, and MAC analyzed independently the title and the abstract of the studies and selected the potential works according to the inclusion and the exclusion criteria. Tables and figures were made by AFS, ILP, PGV, and JPR. ACMR, AFSS, PGV, and ILP drafted the article, and LAG and CCSM critically revised the article.

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Correspondence to Patricia Gabrielli Vassão.

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Sales, A.F.S., Pandolfo, I.L., de Almeida Cruz, M. et al. Intense Pulsed Light on skin rejuvenation: a systematic review. Arch Dermatol Res 314, 823–838 (2022). https://doi.org/10.1007/s00403-021-02283-2

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