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Unbearable transepidermal water loss (TEWL) experimental variability: why?

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Abstract

Despite the wide breadth of research, much disparity exists in transepidermal water loss (TEWL) research data—possibly due to uncontrolled experimental variables. We determined whether such experimental variables significantly impact TEWL studies and cause this disparity. An initial literature search regarding TEWL was performed to determine potential confounding variables. A subsequent search procured relevant and representative studies investigating the impact of these variables on TEWL. Variables, such as age, anatomic site, and temperature, impact TEWL and should be controlled for in TEWL studies. Other variables, such as smoking and menstrual cycle, have inconclusive results or do not provide sufficient data breadth to make a conclusion regarding its effect, if such an effect exists, on TEWL metrics. Therefore, these variables require further research to determine their potential impact on TEWL. Matching for as many experimental variables as possible may reduce the disparity in TEWL data/conclusions.

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  1. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

    Reva P. Peer & Anuk Burli

  2. Department of Dermatology, University of California San Francisco, San Francisco, CA, USA

    Howard I. Maibach

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Peer, R.P., Burli, A. & Maibach, H.I. Unbearable transepidermal water loss (TEWL) experimental variability: why?. Arch Dermatol Res 314, 99–119 (2022). https://doi.org/10.1007/s00403-021-02198-y

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