Abstract
Programmed cell death protein-1 (PD-1) is primarily recognized as an inhibitory receptor involved in the regulation of immunological tolerance. However, recent studies have indicated that PD-1/PD-L1 signaling could also regulate the functions of nonimmune cells and may be involved in regulating hair biology. In this study, we showed in a mouse model of depilation-induced hair cycling that PD-1/PD-L1 are expressed in the murine epidermis and hair follicle (HF) in a hair cycle-dependent manner. During HF morphogenesis, PD-1 expression was strongly decreased during the anagen phase compared with the catagen and telogen phases. PD-L1 expression was enhanced during the catagen phase compared with the anagen and telogen phases. Moreover, direct blockade of PD-L1 not only accelerated hair anagen phase onset but also delayed catagen progression. In conclusion, our findings indicated that PD-1/PD-L1 signaling may act as a negative regulator of hair cycle transition. Anti-PD-1/PD-L1 therapy may thus be a promising strategy for treating anagen-reduced hair loss.
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This study was supported by the National Natural Science Foundation of China (Grant Nos. 81673074, 81972959, 81773350 and 81902409).
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Zhou, L., Wen, L., Sheng, Y. et al. The PD-1/PD-L1 pathway in murine hair cycle transition: a potential anagen phase regulator. Arch Dermatol Res 313, 751–758 (2021). https://doi.org/10.1007/s00403-020-02169-9
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DOI: https://doi.org/10.1007/s00403-020-02169-9