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Efficacy of a wound-dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epidermal grafting in stable vitiligo patients: a controlled assessor-blinded clinical study with in vitro bioactivity investigation

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Abstract

Postinflammatory hyperpigmentation (PIH) is a common disfiguring complication following inflammatory dermatoses and cosmetic procedures in dark-skinned individuals. Anti-inflammatory and repairing agents targeting primary inflammation and injury are becoming promising choices for preventing PIH. The aim of this active-controlled, assessor-blinded, intra-individual monocentric study was to evaluate the preventive effect of a wound-dressing biomaterial, mussel adhesive protein (MAP) in the suction blister-induced PIH model. Twenty Chinese patients underwent suction blister epidermal grafting had defined wound areas to receive a topical MAP spray or a potent corticosteroid cream once daily for seven consecutive days after operation. In situ semi-quantitative evaluations of inflammation and pigmentation were achieved by Mexameter, reflectance confocal microscopy and dermoscopy on week 1, week 4, and week 12. Topical application of MAP exerted remarkably inhibitory effect on PIH comparable to fluticasone propionate, manifested as significantly lower melanin index and papillary contrast measured by Mexameter and confocal microscopy on week 12 compared to untreated sites. Although MAP exhibited moderate anti-inflammatory effect weaker than fluticasone propionate, MAP-treated sites healed faster than steroid-treated and untreated sites. The biological activity of MAP was further studied in UVB-irradiated HaCaT cell model, which revealed MAP decreased the expression of UVB-induced α-melanocyte stimulating hormone (α-MSH) and pro-inflammatory cytokines (IL-1α, IL-6, COX-2). It also protected HaCaT cells from UVB-induced cell death and apoptosis. In conclusion, MAP could be a novel postoperational wound dressing preventing PIH associated with skin inflammation and injury.

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Funding

This research was funded by grants from Natural Science Foundation of China (No. 81602775).

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Author notes

  1. Ziqi Liu, Min Jiang, Juemin Zhao should be considered joint first author.

Authors and Affiliations

  1. Department of Dermatology, Huashan Hospital, Fudan University, No. 12th Middle Wulumuqi Road, Shanghai, 200040, China

    Ziqi Liu, Min Jiang, Juemin Zhao, Qianqian Wang, Chengfeng Zhang & Leihong Xiang

  2. USUN Biochemical Technology Co., Ltd., Jiangyin, China

    Min Gao & Ming Gu

Authors
  1. Ziqi Liu
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  2. Min Jiang
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  3. Juemin Zhao
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  4. Qianqian Wang
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  5. Chengfeng Zhang
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  6. Min Gao
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  7. Ming Gu
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  8. Leihong Xiang
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Contributions

Conceptualization, L-HX, C-FZ and MG; methodology, JM; software, Z-QL; validation, Q-QW, JM and J-MZ; formal analysis, Z-QL; investigation, Z-QL and J-MZ; resources, L-HX, C-FZ and MG; data curation, JM and Q-QW; writing—original draft preparation, Z-QL; writing—review and editing, L-HX and JM; visualization, Z-QL and J-MZ; supervision, C-FZ; project administration, L-HX; funding acquisition, L-HX.

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Correspondence to Leihong Xiang.

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Liu, Z., Jiang, M., Zhao, J. et al. Efficacy of a wound-dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epidermal grafting in stable vitiligo patients: a controlled assessor-blinded clinical study with in vitro bioactivity investigation. Arch Dermatol Res 312, 635–645 (2020). https://doi.org/10.1007/s00403-020-02049-2

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  • DOI: https://doi.org/10.1007/s00403-020-02049-2

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