Skip to main content

Advertisement

SpringerLink
Log in

Identification of bacterial DNA in the peripheral blood of patients with active hidradenitis suppurativa

  • Concise Communication
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Bacterial translocation may have a role in the pathogenesis of several inflammatory conditions. A prospective analytical case–control study was designed to assess the presence of bacterial DNA in the peripheral blood of patients with hidradenitis suppurativa (HS). An age- and gender-matched control population was recruited from healthy blood donors. Demographic and HS-related data were also collected. We took fasting blood samples from each participant and determined the presence of bacterial DNA (including bacterial species identification) and levels TNF-α, IL-1β, and IL-17A. We included 50 patients with HS and 50 healthy controls. Bacterial DNA was present in 17 (34.0%) cases vs. 2 (4.0%) controls (P < 0.001); 14/17 (82.4%) bacterial species identified in HS patients were Gram-negative bacilli, especially Escherichia coli. The presence of bacterial DNA in patients with HS was associated with elevated levels of TNF-α (P < 0.001), IL-1β (P = 0.01) and IL-17 (P < 0.001); however, it was not associated with disease severity or disease location. BactDNA in the peripheral blood of patients with active HS is more common that in healthy controls, and it is associated with higher levels of proinflammatory cytokines. We hypothesized that BT from the skin/intestinal lumen may play a relevant role in the pathogenesis of HS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Guet-Revillet H, Coignard-Biehler H, Jais JP, Quesne G, Frapy E, Poirée S, Le Guern AS, Le Flèche-Matéos A, Hovnanian A, Consigny PH, Lortholary O, Nassif X, Nassif A, Join-Lambert O (2014) Bacterial pathogens associated with hidradenitis suppurativa. France Emerg Infect Dis 20:1990–1998

    Article  CAS  Google Scholar 

  2. Gutiérrez A, Francés R, Amorós A, Zapater P, Garmendia M, Ndongo M, Caño R, Jover R, Such J, Pérez-Mateo M (2009) Cytokine association with bacterial DNA in serum of patients with inflammatory bowel disease. Inflamm Bowel Dis 15:508–514

    Article  Google Scholar 

  3. Lapins J, Jarstrand C, Emtestam L (1999) Coagulase-negative staphylococci are the most common bacteria found in cultures from the deep portions of hidradenitis suppurativa lesions, as obtained by carbon dioxide laser surgery. Br J Dermatol 140:90–95

    Article  CAS  Google Scholar 

  4. Martorell A, Caballero A, González Lama Y, Jiménez-Gallo D, Lázaro Serrano M, Miranda J, Pascual JC, Salgado-Boquete L, Marín-Jiménez I (2016) Management of patients with hidradenitis suppurativa. Actas Dermosifiliogr 107(Suppl 2):32–42

    Article  Google Scholar 

  5. Matusiak Ł, Bieniek A, Szepietowski JC (2014) Bacteriology of hidradenitis suppurative—which antibiotics are the treatment of choice? Acta Derm Venereol 94:699–702

    Article  Google Scholar 

  6. Matusiak Ł, Szczęch J, Bieniek A, Nowicka-Suszko D, Szepietowski JC (2017) Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents. J Am Acad Dermatol 76:670–675

    Article  CAS  Google Scholar 

  7. Nikolakis G, Join-Lambert O, Karagiannidis I, Guet-Revillet H, Zouboulis CC, Nassif A (2015) Bacteriology of hidradenitis suppurativa/acne inversa: a review. J Am Acad Dermatol 73(5 Suppl 1):S12–S18

    Article  Google Scholar 

  8. Perret LJ, Tait CP (2014) Non-antibiotic properties of tetracyclines and their clinical application in dermatology. Australas J Dermatol 5:111–118

    Article  Google Scholar 

  9. Rambhatla PV, Lim HW, Hamzavi I (2012) A systematic review of treatments for hidradenitis suppurativa. Arch Dermatol 148:439–446

    Article  CAS  Google Scholar 

  10. Ramírez-Boscá A, Navarro-López V, Martínez-Andrés A, Such J, Francés R, Horga de la Parte J, Asín-Llorca M. Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis. JAMA Dermatol. 2015;151:670–671.

    Article  Google Scholar 

  11. Ring HC, Emtestam L (2016) The microbiology of hidradenitis suppurativa. Dermatol Clin 34:29–35

    Article  CAS  Google Scholar 

  12. Ring HC, Riis Mikkelsen P, Miller IM, Jenssen H, Fuursted K, Saunte DM, Jemec GB (2015) The bacteriology of hidradenitis suppurativa: a systematic review. Exp Dermatol 24:727–731

    Article  CAS  Google Scholar 

  13. Ring HC, Thorsen J, Saunte DM, Lilje B, Bay L, Theut Riis P, Larsen N, O'Brien Andersen L, Vedel Nielsen H, Miller IM, Bjarnsholt T, Fuursted K, Jemec GB (2018) Moderate to severe hidradenitis suppurativa patients do not have an altered bacterial composition in peripheral blood compared to healthy controls. J Eur Acad Dermatol Venereol 32:125–128

    Article  CAS  Google Scholar 

  14. Such J, Francés R, Muñoz C, Zapater P, Casellas JA, Cifuentes A, Rodríguez-Valera F, Pascual S, Sola-Vera J, Carnicer F, Uceda F, Palazón JM, Pérez-Mateo M (2002) Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. Hepatology 36:135–141

    Article  CAS  Google Scholar 

  15. Sartorius K, Lapins J, Jalal S, Emtestam L, Hedberg M (2006) Bacteraemia in patients with hidradenitis suppurativa undergoing carbon dioxide laser surgery: detection and quantification of bacteria by lysis-filtration. Dermatology 213:305–312

    Article  Google Scholar 

  16. Tsankov N, Grozdev I (2011) Rifampicin—a mild immunosuppressive agent for psoriasis. J Dermatolog Treat 222:62–64

    Article  Google Scholar 

  17. Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhász I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB (2015) European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa. J Eur Acad Dermatol Venereol 29:619–644

    Article  CAS  Google Scholar 

Download references

Funding

Grant from III for Biomedical research grants. Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain (16/143). IRB University Hospital Alicante, Project Number 2016/47.

Author information

Author notes

  1. Patricia Hispán and JoséCarlos Pascual share first authorship

Authors and Affiliations

  1. Department of Dermatology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), C/Maestro Alonso s/n., 03010, Alicante, Spain

    Patricia Hispán, Iris Gonzalez-Villanueva, Jorge Riquelme, Isabel Betlloch & José Carlos Pascual

  2. Department of Digestive Medicine, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain

    Oscar Murcia

  3. Department of Clinical Medicine, CIBERehd_Alicante University General Hospital, Miguel Hernandez University, Alicante, Spain

    Rubén Francés & Paula Giménez

Authors
  1. Patricia Hispán
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Oscar Murcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Iris Gonzalez-Villanueva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rubén Francés
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paula Giménez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jorge Riquelme
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Isabel Betlloch
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. José Carlos Pascual
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to José Carlos Pascual.

Ethics declarations

Conflict of interest

JCP and RF have been an advisory board member for Abbvie. PH, OM, IGV, PG, JR, and IB have no conflicts of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hispán, P., Murcia, O., Gonzalez-Villanueva, I. et al. Identification of bacterial DNA in the peripheral blood of patients with active hidradenitis suppurativa. Arch Dermatol Res 312, 159–163 (2020). https://doi.org/10.1007/s00403-019-01965-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-019-01965-2

Keywords

Search

Navigation