Abstract
The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.
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Abbreviations
- CVI:
-
Chronic venous insufficiency
- DPPH:
-
2,2-Diphenyl-1-picrylhydrazyl
- EGCG:
-
Epigallocatechin gallate
- EIM:
-
Ethanol injection-modified method
- GS–MS:
-
Gas chromatography–mass spectrometry
- GSE:
-
Grape seed extract
- HPLC:
-
High-performance liquid chromatography
- ICD:
-
Irritant contact dermatitis
- LNC:
-
Lipid-core nanocapsule
- MPO:
-
Myeloperoxidase
- NLC:
-
Nanostructured lipid carriers
- PAMAM:
-
Polyamidoamine
- PG:
-
Propylene glycol
- PUVA:
-
Psoralen with ultraviolet-A
- PSR:
-
Psoralen
- RES:
-
Resveratrol
- QUE:
-
Quercetin
- ROS:
-
Reactive oxygen species
- SDC:
-
Deoxycholate
- SNL:
-
Solid–lipid nanoparticles
- TPA:
-
12-O-Tetradecanoylphorbol 13-acetate
- UDL:
-
Ultra-deformable liposomes
- UV:
-
Ultraviolet
- VE:
-
Vitamin E
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Soleymani, S., Iranpanah, A., Najafi, F. et al. Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders. Arch Dermatol Res 311, 577–588 (2019). https://doi.org/10.1007/s00403-019-01930-z
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DOI: https://doi.org/10.1007/s00403-019-01930-z