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Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders

Abstract

The grape seed extract (GSE) and its main active polyphenol, resveratrol (RES), have shown considerable antioxidant activities, besides possessed protective and therapeutic effects against various skin complications. This paper discusses the favorable effects of RES, GSE and their nanoformulations for dermatological approaches, with specific emphasis on clinical interventions. In this manner, electronic databases including PubMed, Science Direct and Google Scholar were searched. Data were collected from 1980 up to February 2019. The search terms included “Vitis vinifera”, “grape”, “resveratrol”, “skin”, “dermatology”, and “nanoformulation”. To increase the skin permeability of GSE and RES, several innovative nanoformulation such as liposomes, niosomes, solid–lipid nanoparticles, nanostructured lipid carriers, and lipid-core nanocapsule has been evaluated. According to our extensive searches, both RES and GSE have beneficial impacts on skin disorders such as chloasma, acne vulgaris, skin aging, as well as wound and facial redness. More clinical studies with nanoformulation approaches are recommended to achieve conclusive outcomes regarding the efficacy of RES and GSE in the management of skin diseases.

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Abbreviations

CVI:

Chronic venous insufficiency

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

EGCG:

Epigallocatechin gallate

EIM:

Ethanol injection-modified method

GS–MS:

Gas chromatography–mass spectrometry

GSE:

Grape seed extract

HPLC:

High-performance liquid chromatography

ICD:

Irritant contact dermatitis

LNC:

Lipid-core nanocapsule

MPO:

Myeloperoxidase

NLC:

Nanostructured lipid carriers

PAMAM:

Polyamidoamine

PG:

Propylene glycol

PUVA:

Psoralen with ultraviolet-A

PSR:

Psoralen

RES:

Resveratrol

QUE:

Quercetin

ROS:

Reactive oxygen species

SDC:

Deoxycholate

SNL:

Solid–lipid nanoparticles

TPA:

12-O-Tetradecanoylphorbol 13-acetate

UDL:

Ultra-deformable liposomes

UV:

Ultraviolet

VE:

Vitamin E

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Soleymani, S., Iranpanah, A., Najafi, F. et al. Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders. Arch Dermatol Res 311, 577–588 (2019). https://doi.org/10.1007/s00403-019-01930-z

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Keywords

  • Skin diseases
  • Nanoformulations
  • Stilbenes
  • Grape extract
  • Resveratrol