Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study


IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results.

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  1. 1.

    Durham LE, Kirkham BW, Taams LS (2015) Contribution of the IL-17 pathway to psoriasis and psoriatic arthritis. Curr Rheumatol Rep 17(8):55

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Krueger JG, Fretzin S, Suarez-Farinas M, Haslett PA, Phipps KM, Cameron GS et al (2012) IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis. J Allergy Clin Immunol 130(1):145 e9–154 e9

    Article  CAS  Google Scholar 

  3. 3.

    Tausend W, Downing C, Tyring S (2014) Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab. J Cutan Med Surg 18(3):156–169

    Article  CAS  PubMed  Google Scholar 

  4. 4.

    Blauvelt A, Papp KA, Griffiths CEM, Puig L, Weisman J, Dutronc Y et al (2018) Correction to: efficacy and safety of switching to ixekizumab in etanercept non-responders: a subanalysis from two phase III randomized clinical trials in moderate-to-severe plaque psoriasis (UNCOVER-2 and-3). Am J Clin Dermatol 19(3):457

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Damiani G, Conic RRZ, de Vita V, Costanzo A, Regazzini R, Pigatto PDM et al (2018) When IL-17 inhibitors fail: real-life evidence to switch from secukinumab to adalimumab or ustekinumab. Dermatol Ther 2018:e12793

    Google Scholar 

  6. 6.

    Georgakopoulos JR, Phung M, Ighani A, Yeung J (2018) Efficacy and safety of switching to ixekizumab in secukinumab nonresponders with plaque psoriasis: a multicenter retrospective study of interleukin 17A antagonist therapies. J Am Acad Dermatol 79(1):155–157

    Article  PubMed  Google Scholar 

  7. 7.

    Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A et al (2011) Definition of treatment goals for moderate to severe psoriasis: a European consensus. Arch Dermatol Res 303(1):1–10

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Alexander A. Navarini.

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Gasslitter, I., Kirsten, N., Augustin, M. et al. Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study. Arch Dermatol Res 311, 421–424 (2019).

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  • Interleukin-17
  • IL-17
  • IL-17A
  • IL-17 receptor blocker
  • Secukinumab
  • Ixekizumab
  • Brodalumab