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Psoriasis and cardiovascular events: updating the evidence

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Abstract

So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0–1.19] and myocardial infarction (MI) (HR = 1.20, 95% CI: 1.06–1.35), but not cardiovascular death. The risks of both stroke (HR = 1.38, 95% CI: 1.20–1.60), MI (HR = 1.70, 95% CI: 1.18–2.43) and cardiovascular death (HR = 1.37, 95% CI: 1.13–1.67) were increased in patients with severe psoriasis. In conclusion, this updated meta-analysis confirmed that patients with psoriasis have an increased risk of CVD, especially those with severe psoriasis.

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Acknowledgements

The authors would like to thank information specialist Tove Faber Frandsen at the Danish Health Authority for assistance in the literature search.

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Authors and Affiliations

  1. Department of Dermatology, Aarhus University Hospital, P.P. Oerumsgade 11, building 15b, 8000, Aarhus, Denmark

    Line Raaby

  2. Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark

    Ole Ahlehoff

  3. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Annette de Thurah

  4. Department of Rheumatology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus, Denmark

    Annette de Thurah

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  1. Line Raaby
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  2. Ole Ahlehoff
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  3. Annette de Thurah
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Correspondence to Line Raaby.

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The authors declare no conflict of interest.

Funding

The study was initiated and financed by the National Danish Health Authority. URL:https://sundhedsstyrelsen.dk/da/udgivelser/2016/nkr-psoriasis.

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For this type of study formal consent is not required.

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Raaby, L., Ahlehoff, O. & de Thurah, A. Psoriasis and cardiovascular events: updating the evidence. Arch Dermatol Res 309, 225–228 (2017). https://doi.org/10.1007/s00403-016-1712-1

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  • DOI: https://doi.org/10.1007/s00403-016-1712-1

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