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Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid

Archives of Dermatological Research volume 308, pages 325–334 (2016)Cite this article

Abstract

Resveratrol is known to inhibit cellular melanin synthesis by multiple mechanisms. Glycolic acid (GA) is used in skin care products for its excellent skin penetration. The purpose of this study was to examine the anti-melanogenic effects of resveratryl triglycolate (RTG), a novel hybrid compound of resveratrol and GA, in comparison with resveratrol, GA, resveratryl triacetate (RTA) and arbutin. Resveratrol, RTG, and RTA inhibited the catalytic activity human tyrosinase (TYR) more potently than arbutin or GA did. Their cytotoxic and anti-melanogenic effects were examined using murine melanoma B16/F10 cells and human epidermal melanocytes (HEMs). The cytotoxicity of RTG was similar to that of resveratrol and RTA. RTG at 3–10 μM decreased melanin levels and cellular TYR activities in α-melanocyte-stimulating hormone-stimulated B16/F10 cells, and l-tyrosine-stimulated HEMs. RTG also suppressed mRNA and protein expression of TYR, tyrosinase-related protein 1, l-3,4-dihydroxyphenylalanine chrome tautomerase, and microphthalmia-associated transcription factor (MITF) in HEMs stimulated with l-tyrosine. This study suggests that, like resveratrol and RTA, RTG can attenuate cellular melanin synthesis effectively through the suppression of MITF-dependent expression of melanogenic enzymes and the inhibition of catalytic activity of TYR enzyme. RTG therefore has potential for use as a cosmeceutical ingredient for skin whitening.

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Acknowledgments

This study was supported by the Korea Health Technology R&D Project of the Ministry of Health and Welfare (HN12C0051).

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Authors and Affiliations

  1. Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 101 Dongin-dong 2-ga, Jung-gu, Daegu, 41944, Republic of Korea

    Soojin Park, Jin Kyung Seok, Jun Yup Kwak & Yong Chool Boo

  2. Bio-Center, Gyeonggi Institute of Science and Technology Promotion, Suwon, Republic of Korea

    Yun-Hyeok Choi & Seong Su Hong

  3. Gyeongbuk Natural Color Industry Institute, Gyeongbuk, Republic of Korea

    Hwa-Jin Suh

  4. DOGENBIO, Seoul, Republic of Korea

    Woncheol Park

  5. Ruby Crown Co. Ltd., Daegu, Republic of Korea

    Yong Chool Boo

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  1. Soojin Park
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  2. Jin Kyung Seok
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Correspondence to Yong Chool Boo.

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Park, S., Seok, J.K., Kwak, J.Y. et al. Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid. Arch Dermatol Res 308, 325–334 (2016). https://doi.org/10.1007/s00403-016-1644-9

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  • DOI: https://doi.org/10.1007/s00403-016-1644-9

Keywords

  • Resveratryl triglycolate
  • Resveratrol
  • Glycolic acid
  • Melanin