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Regulation of lipid production by light-emitting diodes in human sebocytes

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Abstract

Light-emitting diodes (LED) have been used to treat acne vulgaris. However, the efficacy of LED on sebaceous lipid production in vitro has not been examined. This study investigated the efficacy of 415 nm blue light and 630 nm red light on lipid production in human sebocytes. When applied to human primary sebocytes, 415 nm blue light suppressed cell proliferation. Based on a lipogenesis study using Oil Red O, Nile red staining, and thin-layered chromatography, 630 nm red light strongly downregulated lipid production in sebocytes. These results suggest that 415 nm blue light and 630 nm red light influence lipid production in human sebocytes and have beneficial effects on acne by suppressing sebum production.

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Acknowledgments

This study was supported by a Grant of the Traditional Korean Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C0615).

Conflict of interest

The authors state no conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology, College of Medicine, Chungnam National University, 282-Munhwa-ro, Jung-Gu, Daejeon, 301-721, Korea

    Yu Ra Jung, Sue Jeong Kim, Kyung Cheol Sohn, Young Lee, Young Joon Seo, Chang Deok Kim, Jeung Hoon Lee & Myung Im

  2. Department of Anatomy, College of Medicine, Chungnam National University, Daejeon, Korea

    Young Ho Lee

  3. Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, South Korea

    Kyu Uang Whang

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  1. Yu Ra Jung
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  2. Sue Jeong Kim
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  5. Young Joon Seo
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  10. Myung Im
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Correspondence to Myung Im.

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Jung, Y.R., Kim, S.J., Sohn, K.C. et al. Regulation of lipid production by light-emitting diodes in human sebocytes. Arch Dermatol Res 307, 265–273 (2015). https://doi.org/10.1007/s00403-015-1547-1

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  • DOI: https://doi.org/10.1007/s00403-015-1547-1

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