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An association study on the CHRNA5/A3/B4 gene cluster, smoking and psoriasis vulgaris

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Abstract

Genome-wide association and large cohort studies have consistently linked several single nucleotide polymorphisms (SNPs) located in the CHRNA5/A3/B4 gene cluster to smoking behaviors and nicotine dependence. Smoking is one of the well-established environmental risk factors for psoriasis and also associated with severity of the disease. Then we conduct the study to examine whether the genetic variations related to smoking behavior located in the CHRNA5/A3/B4 gene cluster also predict the risk of psoriasis vulgaris (PV). The investigations may help explain the mechanisms of the smoking-PV relationship. This is a hospital base case–control study including 634 subjects (329 PV patients and 305 controls), all Chinese Han population. 8 SNPs were selected based on findings from recent studies on smoking and nicotine dependence, all located in the nicotinic acetylcholine receptor subunits CHRNA5/A3/B4 gene cluster. The variants were typed by SNaPshot Multiplex Kit (Applied Biosystems Co., USA). We confirmed that smoking, alcohol consumption and higher body mass index (BMI ≥25) were risk factors for PV. However, none of the selected SNPs was associated with PV risk in the overall analysis and stratification analysis. And we found no association between the selected SNPs in CHRNA5/A3/B4 gene cluster and the clinical features of PV in case-only analysis. This exploratory study does not provide a relationship between these smoking-related SNPs in the CHRNA5/A3/B4 gene cluster and PV in Chinese Han population.

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Acknowledgments

We are most grateful to the members of all the families who have so willingly participated in this study. This work was supported by grants from Postdoctoral Science Foundation of China (2012M521580); foundation for Distinguished Young Talents in Higher Education of Guangdong Province (2012LYM_0070); the China Natural Science Foundation (81301351); the Natural Science Foundation of Guangdong Province (S2013040012415).

Conflict of interest

The data is an original data, has not been published before and is not being considered for publication elsewhere. The authors state no conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, No. 57, Renmin Avenue, Xiashan District, Zhanjiang, 524001, Guangdong, China

    Kun-Ju Zhu, Zhong Liu, Huan Liu, Shi-Jie Li, Cheng-Yao Zhu & Yi-Ming Fan

  2. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Guangdong Medical College, Zhanjiang, China

    Ke-Shen Li

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  1. Kun-Ju Zhu
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  2. Zhong Liu
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  3. Huan Liu
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  4. Shi-Jie Li
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  5. Cheng-Yao Zhu
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  7. Yi-Ming Fan
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Correspondence to Kun-Ju Zhu, Ke-Shen Li or Yi-Ming Fan.

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Zhu, KJ., Liu, Z., Liu, H. et al. An association study on the CHRNA5/A3/B4 gene cluster, smoking and psoriasis vulgaris. Arch Dermatol Res 306, 939–944 (2014). https://doi.org/10.1007/s00403-014-1510-6

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  • DOI: https://doi.org/10.1007/s00403-014-1510-6

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