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Association of FCGR2A-R/H131 polymorphism with susceptibility to systemic lupus erythematosus among Asian population: a meta-analysis of 20 studies

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Abstract

The results of studies on association between FCGR2A-R/H131 polymorphism and susceptibility to systemic lupus erythematosus (SLE) in the Asian population are controversial. To derive a more precise estimation on the genetic risk of FCGR2A-R/H131 variant for SLE in Asians, a meta-analysis was performed for genotypes R/R + R/H (dominant effect), R/R (recessive effect), and R allele in fixed/random effects models. Twenty studies involving 4,832 SLE patients and 6,190 controls were included. The meta-analysis showed that FCGR2A-R/H131 variant was associated with development of SLE in overall Asians both at allele or genotype level (R vs H, OR 1.201, 95 % CI 1.098–1.315; RR + RH vs HH, OR 1.369, 95 % CI 1.115–1.682; RR vs RH + HH, OR 1.305, 95 % CI 1.029–1.654). After stratification by ethnic, a significant association of R allele with susceptibility to SLE was observed in the Chinese population (R vs H, OR 1.104, 95 % CI 1.030–1.183). Evidence from subgroup analyses in non-Chinese populations (all Asians excluding Chinese population) also showed a significant association (R vs H, OR 1.354, 95 % CI 1.207–1.519; RR + RH vs HH, OR 1.705, 95 % CI 1.234–2.355). In addition, FCGR2A-R131 allele was associated with a 1.186-fold (95 % CI 1.043–1.349) greater risk for the occurrence of nephritis in the Asians population with SLE. After stratification by ethnic, this significant association was only consistently identified in non-Chinese populations (R vs H, OR 1.220, 95 % CI 1.002–1.486). In summary, FCGR2A-R/H131 polymorphism is associated with SLE and lupus nephritis in Asians.

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Acknowledgments

This work was partly supported by grants from the key program of National Natural Science Foundation of China (81172764).

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The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Rui Li, Chen-Chen Feng, Yu-Jing Zhang, Peng-Fei Wen, Li-Juan Qiu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

  2. Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Rui Li, Chen-Chen Feng, Yu-Jing Zhang, Peng-Fei Wen, Li-Juan Qiu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

  3. The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, Anhui, People’s Republic of China

    Hui Peng

  4. School of Health Management, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Gui-Mei Chen

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  1. Rui Li
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Li, R., Peng, H., Chen, GM. et al. Association of FCGR2A-R/H131 polymorphism with susceptibility to systemic lupus erythematosus among Asian population: a meta-analysis of 20 studies. Arch Dermatol Res 306, 781–791 (2014). https://doi.org/10.1007/s00403-014-1483-5

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