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Archives of Dermatological Research

, Volume 304, Issue 7, pp 499–510 | Cite as

The role of androgen and androgen receptor in skin-related disorders

  • Jiann-Jyh Lai
  • Philip Chang
  • Kuo-Pao Lai
  • Lumin Chen
  • Chawnshang ChangEmail author
Review Article

Abstract

Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris. Current treatments for these androgen/AR-involved diseases, which target the synthesis of androgens or prevent its binding to AR, can cause significant adverse side effects. Based on the recent studies using AR knockout mice, it has been suggested that AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases. Here, we review recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing.

Keywords

Androgen Androgen receptor Wound healing Androgenetic alopecia Acne vulgaris Hirsutism 

Notes

Acknowledgments

We thank Karen Wolf for help in preparing the manuscript. This work was supported by George Whipple Professorship Endowment, NIH grant DK73414, and Department of Health Clinical Trial and Research Center of Excellence grant DOH99-TD-B-111-004 to China Medical University, Taichung, Taiwan.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Jiann-Jyh Lai
    • 1
  • Philip Chang
    • 1
  • Kuo-Pao Lai
    • 1
  • Lumin Chen
    • 1
    • 2
  • Chawnshang Chang
    • 1
    • 2
    Email author
  1. 1.George Whipple Lab for Cancer Research, Departments of Pathology and Urology and The Wilmot Cancer CenterUniversity of Rochester Medical CenterRochesterUSA
  2. 2.Sex Hormone Research CenterChina Medical UniversityTaichungTaiwan

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