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Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis

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Abstract

Platelet-activating factor acetylhydrolase (PAF-AH) has been demonstrated to be one of anti-inflammatory and anti-apoptotic factors, suggesting the potential to be involved in the development of systemic sclerosis (SSc). The aim of this study is to determine serum PAF-AH levels and their clinical associations in patients with SSc. Serum PAF-AH levels were examined by enzyme-linked immunosorbent assay in 57 patients with SSc and 24 healthy individuals. Serum PAF-AH levels were significantly elevated in SSc patients (130.4 ± 69.5 ng/ml) compared with healthy individuals (81.6 ± 34.8 ng/ml; P < 0.001). Among SSc patients, there were no differences in serum PAF-AH levels between those with diffuse cutaneous SSc (135.5 ± 79.3 ng/ml; n = 29) and those with limited cutaneous SSc (125.1 ± 58.6 ng/ml; n = 28). Patients with SSc who had raised PAF-AH levels less often had digital ulcers and arthritis/arthralgias than those with normal PAF-AH levels. The results show that serum PAF-AH levels were increased in patients with SSc and associated with a lower frequency of pitting scars/digital ulcers and arthritis/arthralgias. PAF-AH could be a protective factor against the development of digital ulcers and arthritis/arthralgia in this disease and as such would be a useful serological marker for disease severity.

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Acknowledgments

This work was supported by a grant for Research on Intractable Diseases from the Ministry of Health, Labor and Welfare of Japan.

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The authors have expressed no conflicts of interest.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Koichi Yanaba, Yoshihide Asano, Yayoi Tada, Makoto Sugaya, Takafumi Kadono & Shinichi Sato

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  1. Koichi Yanaba
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  2. Yoshihide Asano
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  3. Yayoi Tada
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  4. Makoto Sugaya
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  5. Takafumi Kadono
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Correspondence to Koichi Yanaba.

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Yanaba, K., Asano, Y., Tada, Y. et al. Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis. Arch Dermatol Res 304, 203–208 (2012). https://doi.org/10.1007/s00403-011-1196-y

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  • DOI: https://doi.org/10.1007/s00403-011-1196-y

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