Archives of Dermatological Research

, Volume 303, Issue 10, pp 737–744 | Cite as

Aromatic-turmerone inhibits α-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways

  • Sun Young Park
  • Mei Ling Jin
  • Young Hun Kim
  • YoungHee Kim
  • Sang-Joon LeeEmail author
Original Paper


This study investigated the anti-melanogenic effect of aromatic (ar)-turmerone on alpha-melanocyte stimulating hormone (α-MSH) and 3-isobuty-1-methxlzanthine (IBMX)-induced tyrosinase (Tyr), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) expression in B16F10 melanoma cells. We demonstrated that ar-turmerone inhibits α-MSH and IBMX-induced melanin synthesis and tyrosinase activity. Data also showed that ar-turmerone inhibits the expression of tyrosinase, TRP-1, and TRP-2 in α-MSH- and IBMX-stimulated B16F10 cells. In addition, ar-turmerone exhibits stronger anti-melanogenic effects than curcumin. Furthermore, ar-turmerone strongly inhibited α-MSH- and IBMX-induced microphthalmia-associated transcription factor by suppressing the activity of cyclic adenosine monophosphate (cAMP)-responsive element binding protein in α-MSH-stimulated B16F10 cells. Our data revealed that ar-turmerone is a novel, effective, anti-melanogenic agent that functions by downregulating tyrosinase, Trp-1, and Trp-2 gene expression. Therefore, ar-turmerone may be a useful therapeutic agent for treating hyperpigmentation disorders, such as freckles and melasma, and as a beneficial additive in whitening cosmetics.


Ar-turmerone Melanin Tyrosinase cAMP-responsive element binding protein (CREB) Microphthalmia-associated transcription factor (MITF) 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Sun Young Park
    • 1
  • Mei Ling Jin
    • 3
  • Young Hun Kim
    • 1
  • YoungHee Kim
    • 2
  • Sang-Joon Lee
    • 3
    Email author
  1. 1.Bio-IT Fusion Technology Research InstitutePusan National UniversityBusanRepublic of Korea
  2. 2.Department of Molecular BiologyPusan National UniversityBusanRepublic of Korea
  3. 3.Department of MicrobiologyPusan National UniversityBusanRepublic of Korea

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